{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T19:19:47Z","timestamp":1761765587562,"version":"3.40.4"},"reference-count":16,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Aim:&lt;\/i&gt;&lt;\/b&gt; To develop a new optical device (prostate optical device, POD) for assessment of prostate tissue stiffness and evaluate its sensitivity and specificity in prostate cancer detection. &lt;b&gt;&lt;i&gt;Patients and Methods:&lt;\/i&gt;&lt;\/b&gt; POD was tested in prostate phantoms and in patients with indications for prostate biopsy. Its sensitivity and specificity were compared to digital rectal examination (DRE) and transrectal ultrasonography (TRUS). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; POD was able to identify stiffness differences on each prostate phantom. 45 patients were included in the study. Sensitivity of TRUS (40%) was significantly lower to POD (85.7%) and DRE (74.3%) (p = 0.000 and p = 0.003, respectively). There was no statistical difference between POD and DRE (p = 0.221). The combination of POD and DRE showed the highest sensitivity (88.6%), positive predictive value (81.6%), and negative predictive value (42.9%) among all diagnostic tests. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; POD identified prostatic stiffness differences with the same sensitivity of DRE performed by an experienced urologist providing an objective indication for prostate biopsy and early prostate cancer detection.<\/jats:p>","DOI":"10.1159\/000339966","type":"journal-article","created":{"date-parts":[[2012,9,17]],"date-time":"2012-09-17T06:56:19Z","timestamp":1347864979000},"page":"290-295","source":"Crossref","is-referenced-by-count":3,"title":["Development of a New Optical Device and Its Feasibility in Prostate Cancer Detection"],"prefix":"10.1159","volume":"89","author":[{"given":"Sofia D.","family":"Panteliou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vassilios","family":"Tzortzis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"George T.","family":"Anagnostopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.M.","family":"Sunaric","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Sarris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Hatzimouratidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitris","family":"Hatzichristou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,9,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2010.10.039"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0090-4295%2893%2990359-I"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.b3537"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.urology.2007.06.1092"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2896%2900632-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2008.02.035"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-410X.2011.10209.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ultrasmedbio.2011.05.014"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053%2Fcrad.2002.0989"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0924-4247%2892%2987002-X"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291520-6777%281996%2915%3A1%3C85%3A%3AAID-NAU9%3E3.0.CO%3B2-B"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.media.2007.10.001"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.media.2009.10.006"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.urology.2010.02.025"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1115%2F1.2898712"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.media.2005.05.002"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339966","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/339966","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:34:15Z","timestamp":1745433255000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000339966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":16,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,10,1]]},"published-print":{"date-parts":[[2012,10,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000339966","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"type":"print","value":"0042-1138"},{"type":"electronic","value":"1423-0399"}],"subject":[],"published":{"date-parts":[[2012]]}}}