{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:36:17Z","timestamp":1761597377804,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2012,9,26]],"date-time":"2012-09-26T00:00:00Z","timestamp":1348617600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,9,26]],"date-time":"2012-09-26T00:00:00Z","timestamp":1348617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Previous studies showed that a recombinant bacille Calmette-Gu\u00e9rin (rBCG) which expressed the Der p 2 of house dust mites (Der p 2 rBCG) could suppress asthmatic airway inflammation. There are two possible mechanisms: (1) Der p 2 rBCG elicits immune deviation from Th2 to Th1, and (2) Der p 2 rBCG induces antigen-specific regulatory T cells. However, the role of dendritic cell (DC) Der p 2 rBCG in this protective effect and in reprogramming T-cell commitment still needs to be studied. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; The aim of this study was to determine whether DCs play a central role in the Der p 2 rBCG-mediated inhibition of allergic airway inflammation. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; DCs were collected from Der p 2 rBCG-immunized mice (Der p 2 rBCG-DCs) and adoptively transferred to Der p 2-sensitized mice. The effects of DCs on airway inflammation and immune regulation were analyzed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Adoptive transfer of DCs from Der p 2 rBCG-immunized mice suppressed asthmatic responses, including airway inflammation, mucin secretion and airway responsiveness. Der p 2 rBCG-DCs could effectively inhibit excessive Th2 immune responses and induced a subtype of CD4+CD25+Foxp3+ anti-specific regulatory T cells in this asthma model. Furthermore, Der p 2 rBCG immunization recruited more plasmacytoid DCs in abdominal draining lymph nodes. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; These findings suggest that DCs played a key role in Der p 2 rBCG-induced immunoregulation. Compared with BCG, Der p 2 rBCG displayed a more potent inhibitory effect on asthma responses, which may be related to the increase in plasmacytoid DC recruitment. These results improve our understanding of the cellular basis of Der p 2 BCG-mediated inhibition of asthma.<\/jats:p>","DOI":"10.1159\/000340007","type":"journal-article","created":{"date-parts":[[2012,9,27]],"date-time":"2012-09-27T01:53:51Z","timestamp":1348710831000},"page":"49-58","source":"Crossref","is-referenced-by-count":9,"title":["Der p 2 Recombinant Bacille Calmette-Gu\u00e9rin Targets Dendritic Cells to Inhibit Allergic Airway Inflammation in a Mouse Model of Asthma"],"prefix":"10.1159","volume":"85","author":[{"given":"Shuo-Yao","family":"Qu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai-Feng","family":"Ou-Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ya-Long","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Wan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie-Ran","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Gui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,9,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000330013"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.tips.2010.04.009"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.0019-2805.2002.01377.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.187.4.561"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2567.2008.02970.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4049%2Fjimmunol.0902829"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000222673"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186%2F1476-4598-9-90"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.96.3.1036"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2007.08.038"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2174%2F138955707780363828"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20040035"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20061660"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2003.10.067"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-3083.2007.02050.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2003-09-3302"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.4049%2Fjimmunol.0901822"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/340007","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/340007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:34:25Z","timestamp":1745433265000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000340007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,26]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,12,1]]},"published-print":{"date-parts":[[2013,1,3]]}},"URL":"https:\/\/doi.org\/10.1159\/000340007","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"type":"print","value":"0025-7931"},{"type":"electronic","value":"1423-0356"}],"subject":[],"published":{"date-parts":[[2012,9,26]]}}}