{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T04:14:07Z","timestamp":1770437647581,"version":"3.49.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T00:00:00Z","timestamp":1348099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T00:00:00Z","timestamp":1348099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Respiration"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Aortic dissection is a life-threatening manifestation of Marfan's syndrome. Preliminary evidence suggests that obstructive sleep apnea (OSA) is associated with aortic disease in Marfan's syndrome. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; To study the effect of OSA on aortic events in Marfan's syndrome. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; In patients with Marfan's syndrome, a sleep study was performed at baseline and OSA was defined as &gt;5 events of apnea\/hypopnea (A+H) per hour in bed. Operation because of progressive aortic dilatation and death because of aortic rupture were defined as \u2018aortic events'. Kaplan-Meier survival analyses were used to compare event-free survival in patients with and without OSA. Cox regression models were used to explore the effects of covariates on event-free survival. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Data from 44 patients (mean age 37.4 years, 30 females) were available for analysis; 15 patients (34.1%) had OSA. The median follow-up time was 29 (interquartile range 24-36) months. Five patients had an aortic event within the follow-up time. Median event-free survival was 51.6 months. Event-free survival was significantly shorter in patients with OSA compared to patients without OSA (p = 0.012). In univariate analysis, A+H was associated with aortic events [hazard ratio (HR) 1.09, 95% confidence interval (CI) 1.01-1.18, p = 0.023]. Taking the interaction between BMI and A+H into account increased the HR for A+H (HR 1.75, 95% CI 1.003-3.048, p = 0.049). This association was no longer significant when other covariates were forced into the multivariate analysis. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; These data suggest that aortic event-free survival may be shorter in patients with Marfan's syndrome and OSA compared to patients without OSA, but more data from well-designed studies are needed to prove this association.<\/jats:p>","DOI":"10.1159\/000340008","type":"journal-article","created":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T08:27:18Z","timestamp":1348129638000},"page":"39-44","source":"Crossref","is-referenced-by-count":43,"title":["The Impact of Obstructive Sleep Apnea on Aortic Disease in Marfan's Syndrome"],"prefix":"10.1159","volume":"86","author":[{"given":"Malcolm","family":"Kohler","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alex","family":"Pitcher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward","family":"Blair","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Risby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oliver","family":"Senn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin","family":"Forfar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"Wordsworth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John R.","family":"Stradling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,9,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)67789-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.108.783753"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19960424)62:4<417::AID-AJMG15>3.3.CO;2-S"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/humu.20070"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2009.072785"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(94)90405-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1378\/chest.108.3.631"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm\/147.3.645"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/thx.2008.102756"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046\/j.0009-9163.2002.00002.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2799"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-812423"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(89)90430-X"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2010.31"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/0003-4975(91)91414-Q"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.11.116"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200304-566OC"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201001-0051OC"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2010.01.369"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1172\/JCI118235"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1001\/jama.283.7.897"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.149.3.8118640"}],"container-title":["Respiration"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/340008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/340008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:34:26Z","timestamp":1745433266000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000340008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,20]]},"references-count":22,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,7,1]]},"published-print":{"date-parts":[[2013,7,11]]}},"URL":"https:\/\/doi.org\/10.1159\/000340008","archive":["Portico"],"relation":{},"ISSN":["0025-7931","1423-0356"],"issn-type":[{"value":"0025-7931","type":"print"},{"value":"1423-0356","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,20]]}}}