{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T22:56:19Z","timestamp":1770504979730,"version":"3.49.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T00:00:00Z","timestamp":1347926400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T00:00:00Z","timestamp":1347926400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To study the effect of erythropoietin (EPO) treatment on renal and lung injury following renal ischemia\/reperfusion (I\/R). &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;\/i&gt;&lt;\/b&gt; Thirty male Wistar rats were assigned to three groups of 10 rats each. The first group was sham-operated, the second was subjected to renal I\/R (30 min of ischemia followed by 24 h of reperfusion). The third group was subjected to renal I\/R and treated with EPO in two doses: the first dose 1 h prior to ischemia (1,000 U\/kg) and the second dose 6 h after ischemia (1,000 U\/kg). &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The renal and lung tissue injury index, tissue serum blood urea nitrogen and creatinine (Cr) were higher in the renal I\/R group compared to the renal I\/R + EPO group; the difference was statistically significant (p &lt; 0.05). Kidney and lung tissue glutathione peroxidase and superoxide dismutase levels were higher in the renal I\/R + EPO group than the renal I\/R group; the difference was also statistically significant (p &lt; 0.05). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The data showed that EPO pretreatment could be effective in reducing renal and lung injury following renal I\/R and could improve the cellular antioxidant defense system. Hence EPO pretreatment may be effective for attenuating renal and lung injury after renal I\/R-induced injury during surgical procedures, hypotension, renal transplantation and other conditions inducing renal I\/R.<\/jats:p>","DOI":"10.1159\/000340060","type":"journal-article","created":{"date-parts":[[2012,9,18]],"date-time":"2012-09-18T07:45:38Z","timestamp":1347954338000},"page":"70-74","source":"Crossref","is-referenced-by-count":32,"title":["Erythropoietin Ameliorates Oxidative Stress and Tissue Injury following Renal Ischemia\/Reperfusion in Rat Kidney and Lung"],"prefix":"10.1159","volume":"22","author":[{"given":"Mohammad 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