{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T07:12:33Z","timestamp":1793517153689,"version":"4.5.0"},"reference-count":17,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Septo-optic dysplasia (SOD) is a disorder with postulated environmental and genetic aetiology. This study delineates clinical features and potential perinatal environmental factors along with epidemiology in SOD children. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Assessment of patients with SOD triad features in the UK West Midlands region. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Of 227 patients identified between 1998 and 2009 with 1 or more feature of the triad, 55 had midline defects, 149 had optic nerve hypoplasia and 132 had hypopituitarism. Eighty-eight children (52% males; incidence 8.3\/100,000 live births) had SOD defined as 2 out of 3 features and 21 (24%) had all 3. Sixty-one percent had anterior pituitary deficiency and 21.5% had diabetes insipidus. Median maternal\/paternal ages in SOD were 21 and 23.5 years, compared to UK means of 29.3 and 32.4 years (p &lt; 0.001). First trimester bleeding was markedly increased at 12\/48 (25%) compared to 0.07% in the UK (p &lt; 0.001). Ethnicity showed a non-significant higher prevalence in Afro-Caribbean and mixed race groups, and significantly lower prevalence (p = 0.004) in South Asian groups compared to West Midland and Birmingham city data: 8% versus 2.5 and 6.7%, 9% versus 1.8 and 3.2% and 3% versus 8.4 and 21%, respectively. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; SOD is associated with younger maternal and paternal age, primigravida births and ethnic differences. Increased first trimester bleeding may indicate that SOD is a vascular disruption sequence.<\/jats:p>","DOI":"10.1159\/000341148","type":"journal-article","created":{"date-parts":[[2012,8,14]],"date-time":"2012-08-14T06:16:52Z","timestamp":1344925012000},"page":"81-87","source":"Crossref","is-referenced-by-count":42,"title":["Septo-Optic Dysplasia: Antenatal Risk Factors and Clinical Features in a Regional Study"],"prefix":"10.1159","volume":"78","author":[{"given":"Navoda","family":"Atapattu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Ainsworth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry","family":"Willshaw","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Parulekar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lesley","family":"MacPherson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claire","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Davies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy M.W.","family":"Kirk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,8,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2870%2991717-4"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.pediatrneurol.2005.07.004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2005.07.031"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2F477"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.beem.2010.06.008"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1996.tb14044.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2002-021868"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2879%2980392-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1515%2FJPEM.2005.18.5.471"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1755-3768.2008.01450.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.crad.2007.07.008"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0387-7604%2886%2980075-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004310051026"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.70.1.51"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000181883"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-8628%2819970331%2969%3A3%3C235%3A%3AAID-AJMG4%3E3.0.CO%3B2-K"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000232943"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/341148","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/341148","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:36:04Z","timestamp":1745418964000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000341148"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,9,1]]},"published-print":{"date-parts":[[2012,9,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000341148","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}