{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:34:54Z","timestamp":1745469294217,"version":"3.40.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aim:&lt;\/i&gt;&lt;\/b&gt; Periodic endoscopy for esophageal varices (EVs) and prophylactic treatment of high-risk EVs, i.e. medium\/large EVs, small EVs with the red-color sign or decompensation, are recommended in cirrhotic patients. We assessed the cumulative risks for future EV bleeding using the following simple P2\/MS index: (platelet count)&lt;sup&gt;2&lt;\/sup&gt;\/[monocyte fraction (%) \u00d7 segmented neutrophil fraction (%)]. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We enrolled 475 consecutive B-viral cirrhosis patients for 4 years, none of whom experienced EV bleeding. All underwent laboratory work-ups, endoscopy and ultrasonography. Those with EV bleeding took a nonselective \u03b2-blocker as prophylaxis. The major endpoint was the first occurrence of EV bleeding, analyzed using the Kaplan-Meier and Cox regression methods. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Among patients with EV bleeding (n = 131), 25 experienced their first EV bleeding during follow-up. To differentiate the risk for EV bleeding, we divided them into two subgroups according to their P2\/MS value (subgroup 1: P2\/MS \u22659 and subgroup 2: P2\/MS &lt;9). The risk was significantly higher in subgroup 2 (p = 0.029). From multivariate analysis, a lower P2\/MS (p = 0.040) remained a significant predictor for EV bleeding along with large varix size (p = 0.015), red-color sign (p = 0.041) and Child-Pugh classification B\/C (p = 0.001). In subgroup 1, the risk for EV bleeding was similar to that of patients with low-risk EVs (p = 0.164). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; The P2\/MS is a reliable predictor for the risk of EV bleeding among patients with EV bleeding. According to risk stratification, different prophylactic treatments should be considered for the subgroup with a P2\/MS &lt;9.<\/jats:p>","DOI":"10.1159\/000341507","type":"journal-article","created":{"date-parts":[[2012,9,17]],"date-time":"2012-09-17T07:08:29Z","timestamp":1347865709000},"page":"264-272","source":"Crossref","is-referenced-by-count":2,"title":["Prediction of Esophageal Variceal Bleeding in B-Viral Liver Cirrhosis Using the P2\/MS Noninvasive Index Based on Complete Blood Counts"],"prefix":"10.1159","volume":"86","author":[{"given":"Beom Kyung","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Hoon","family":"Ahn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwang-Hyub","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun 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Young","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,9,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jhep.2008.01.021"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0168-8278%2802%2900420-8"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.2009.201434"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.21907"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2893.2009.01091.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1478-3231.2010.02260.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra0901512"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2000.03204.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jhep.2008.08.018"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jhep.2006.04.006"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.21665"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jhep.2008.10.001"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs12072-008-9080-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.23190"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0006-341X.2000.00337.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1002%2Fbimj.200410135"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2008.01826.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1478-3231.2008.01789.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1478-3231.2008.01900.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1053%2Fjhep.2003.50133"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002%2Fhep.23617"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1478-3231.2010.02317.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097%2FMCG.0b013e318157464b"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2036.2006.02889.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2257.1995.tb00319.x"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/341507","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/341507","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/341507","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:39:10Z","timestamp":1745433550000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000341507"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,10,1]]},"published-print":{"date-parts":[[2012,10,30]]}},"URL":"https:\/\/doi.org\/10.1159\/000341507","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"type":"print","value":"0012-2823"},{"type":"electronic","value":"1421-9867"}],"subject":[],"published":{"date-parts":[[2012]]}}}