{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T03:20:18Z","timestamp":1767842418020,"version":"3.49.0"},"reference-count":27,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Obes Facts"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective: &lt;\/i&gt;&lt;\/b&gt;To assess the effects of weight loss on serum adipokine levels in polycystic ovary syndrome (PCOS). &lt;b&gt;&lt;i&gt;Methods: &lt;\/i&gt;&lt;\/b&gt;We determined serum leptin, adiponectin, resistin, and visfatin levels in 60 overweight\/obese women with PCOS and 48 BMI-matched female volunteers. Measurements were repeated after 24 weeks of treatment with orlistat 120 mg 3 times per day along with an energy-restricted diet. &lt;b&gt;&lt;i&gt;Results: &lt;\/i&gt;&lt;\/b&gt;At baseline,&lt;b&gt; &lt;\/b&gt;serum visfatin concentration was higher in patients with PCOS than in controls (p = 0.036); serum levels of leptin, adiponectin, and resistin did not differ between the two groups. After 24 weeks, a significant reduction in BMI and waist circumference was observed in both patients with PCOS and controls (p &lt; 0.001 vs. baseline in both groups). Also serum leptin levels decreased in both patients with PCOS and controls (p &lt; 0.001 vs. baseline in both groups). The reduction in serum leptin levels did not differ between groups. Serum adiponectin, resistin, and visfatin levels did not change in either group. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Leptin, adiponectin, and resistin do not appear to play major pathogenetic roles in overweight\/obese patients with PCOS. In contrast, visfatin emerges as a potentially important mediator of the endocrine abnormalities of these patients. However, serum visfatin levels are not substantially affected by weight loss.<\/jats:p>","DOI":"10.1159\/000341579","type":"journal-article","created":{"date-parts":[[2012,7,23]],"date-time":"2012-07-23T08:28:01Z","timestamp":1343032081000},"page":"495-504","source":"Crossref","is-referenced-by-count":25,"title":["Adipokines, Insulin Resistance and Hyperandrogenemia in Obese Patients with Polycystic Ovary Syndrome: Cross-Sectional Correlations and the Effects of Weight Loss"],"prefix":"10.1159","volume":"5","author":[{"given":"Nikolaos","family":"Spanos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Konstantinos","family":"Tziomalos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Djuro","family":"Macut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ekaterini","family":"Koiou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleni A.","family":"Kandaraki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Delkos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Tsourdi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Panidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,7,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2807%2961345-2"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00404-006-0171-x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2008-1613"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3109%2F09513590903247873"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.rbmo.2009.05.010"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4149%2Fendo_2010_01_25"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2008.05.065"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-2336"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2003.08.023"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1152%2Fajpendo.90684.2008"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1053%2Fmeta.2002.31975"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00280883"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.7.2402"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3109%2F09513590.2010.495796"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fdem118"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-0936"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2003-031205"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.1.01868"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjmed.2005.10.059"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fdel146"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumupd%2Fdmp006"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2F13.3.535"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.82.6.1692"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.82.6.1687"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fdeg353"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2008-2156"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2008.10.058"}],"container-title":["Obesity Facts"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/341579","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/341579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:39:29Z","timestamp":1745433569000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000341579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000341579","archive":["Portico"],"relation":{},"ISSN":["1662-4025","1662-4033"],"issn-type":[{"value":"1662-4025","type":"print"},{"value":"1662-4033","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}