{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T11:36:31Z","timestamp":1790681791482,"version":"4.1.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Surg Res"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Purpose:&lt;\/i&gt;&lt;\/b&gt; It has been substantiated that the quality of pleurodesis is reduced when non-steroidal anti-inflammatory drugs (NSAIDs) are used perioperatively. The effects of NSAID administration on the early inflammatory and fibrinolytic processes after mechanical pleurodesis were investigated in an established pig model. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Left-sided mechanical pleural abrasion was performed on 24 pigs assigned to either an NSAID or a control group. Pleural fluid and blood samples were analysed over a 24-hour period. Histological evaluation of neutrophil influx at the site of pleural abrasion was performed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The volume of pleural effusion was significantly decreased in the diclofenac group at 10 and 24 h, and the protein content was significantly lower. The diclofenac group at 24 h had a diminished total number of white blood cells and a reduced content of transforming growth factor-\u03b2. Moreover, the diclofenac group had a reduced percentage of neutrophils at 6 h. Significantly increased levels of D-dimers and tissue plasminogen activator were measured at 6 h and of interleukin-10 at 24 h. Neutrophils at the site of pleural abrasion were significantly reduced. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Systemic application of diclofenac led to a local enhancement of fibrinolysis and attenuation of pro-inflammatory and fibrotic processes necessary for adhesion formation in our model.<\/jats:p>","DOI":"10.1159\/000341670","type":"journal-article","created":{"date-parts":[[2013,2,15]],"date-time":"2013-02-15T14:26:34Z","timestamp":1360938394000},"page":"14-23","source":"Crossref","is-referenced-by-count":10,"title":["Perioperative Diclofenac Application during Video-Assisted Thoracic Surgery Pleurodesis Modulates Early Inflammatory and Fibrinolytic Processes in an Experimental Model"],"prefix":"10.1159","volume":"50","author":[{"given":"Isabelle","family":"Opitz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Arni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birgit","family":"Oberreiter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars M.","family":"Asmis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Vogt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentin","family":"Rousson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Weder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Didier","family":"Lardinois","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,2,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejcts.2004.01.028"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.128.6.4041"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-6980%2898%2900064-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10753-006-9013-z"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00011-006-0008-x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.rmed.2006.09.007"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.97.10102411"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.127.4.1335"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.06.00037906"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.109.1.309"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI117853"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M205142200"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.pain.2006.09.011"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004240100718"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2Fs000110050474"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1093%2Fbja%2F88.6.797"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1472-8206.2002.00093.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1510%2Ficvts.2006.140400"}],"container-title":["European Surgical Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/341670","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/341670","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/341670","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:39:57Z","timestamp":1745433597000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000341670"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,5,1]]},"published-print":{"date-parts":[[2013,5,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000341670","archive":["Portico"],"relation":{},"ISSN":["0014-312X","1421-9921"],"issn-type":[{"value":"0014-312X","type":"print"},{"value":"1421-9921","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}