{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T20:26:13Z","timestamp":1769027173307,"version":"3.49.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T00:00:00Z","timestamp":1346716800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2012,9,4]],"date-time":"2012-09-04T00:00:00Z","timestamp":1346716800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Med Princ Pract"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Objective:<\/i><\/b> To study the effects of pioglitazone on endothelial dysfunction of subjects with impaired glucose regulation (IGR) among the first-degree relatives of patients with type 2 diabetes mellitus (T2DM). <b><i>Subjects and Methods:<\/i><\/b> The first-degree relatives of T2DM patients were screened with oral glucose test and IGR was diagnosed. IGR subjects whose blood glucose was still above the level after 1-month exercise were randomized to receive pioglitazone (15 mg\/day) or vehicle for 12 weeks. Endothelial function was assessed as endothelium-dependent and -independent vasodilation. Blood nitric oxide (NO), blood pressure, body mass index, insulin and serum lipids were also measured. Area under the curve of glucose (AUC<sub>glu<\/sub>) and insulin (AUC<sub>INS<\/sub>), homeostasis model assessment of insulin resistance (HOMA-IR), HOMA of \u03b2-cell function (HOMA-\u03b2) and early insulin secretion index (\u0394I<sub>30<\/sub>\/\u0394G<sub>30<\/sub>) were calculated. <b><i>Results:<\/i><\/b> After pioglitazone treatment, fasting plasma, 2-hour plasma glucose, triglyceride (TG), fasting insulin, AUC<sub>glu<\/sub>, HOMA-\u03b2 and HOMA-IR, 2-hour insulin, AUC<sub>INS<\/sub> and \u0394I<sub>30<\/sub>\/\u0394G<sub>30<\/sub> decreased. Endothelium-dependent vasodilation and NO were significantly improved in the treatment group. Furthermore, the changes of endothelium-dependent vasodilation were negatively correlated with changes in AUC<sub>INS<\/sub> but positively with NO and HOMA-\u03b2. Stepwise multivariate regression analysis showed that changes in NO and HOMA-\u03b2 were both independent parameters for improvement of endothelial dysfunction. <b><i>Conclusion:<\/i><\/b> Pioglitazone decreased blood glucose and TG, increased insulin sensitivity, and ameliorated endothelial dysfunction of IGR subjects among the first-degree relatives of T2DM patients. Increased NO production may be associated with the improvement of endothelial dysfunction.<\/jats:p>","DOI":"10.1159\/000341770","type":"journal-article","created":{"date-parts":[[2012,9,12]],"date-time":"2012-09-12T08:06:39Z","timestamp":1347437199000},"page":"156-160","source":"Crossref","is-referenced-by-count":12,"title":["Pioglitazone Ameliorates Endothelial Dysfunction in Those with Impaired Glucose Regulation among the First-Degree Relatives of Type 2 Diabetes Mellitus Patients"],"prefix":"10.1159","volume":"22","author":[{"given":"Xuemei","family":"Yu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peihong","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongtao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,9,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Foby.2003.174"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.101.15.1780"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2337%2Fdc07-1868"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa1010949"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiacare.27.2.484"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2892%2993147-F"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00125-012-2534-0"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiacare.27.1.47"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2174%2F1568006043481275"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.105.563213"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiacare.24.3.447"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiacare.22.1.45"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000204355"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00395-011-0237-1"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.atherosclerosis.2010.12.021"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1463-1326.2010.01224.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.atherosclerosis.2009.12.011"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.diabres.2011.07.036"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1177%2F1479164111424515"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.atherosclerosis.2008.11.027"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.atherosclerosis.2012.01.029"}],"container-title":["Medical Principles and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/341770","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/341770","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/341770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:41:13Z","timestamp":1745433673000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000341770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,4]]},"references-count":21,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,1,1]]},"published-print":{"date-parts":[[2013,1,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000341770","archive":["Portico"],"relation":{},"ISSN":["1011-7571","1423-0151"],"issn-type":[{"value":"1011-7571","type":"print"},{"value":"1423-0151","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,4]]}}}