{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T22:33:58Z","timestamp":1792708438191,"version":"4.5.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T00:00:00Z","timestamp":1345766400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,8,24]],"date-time":"2012-08-24T00:00:00Z","timestamp":1345766400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To estimate the odds of severe cerebral injury and long-term neurodevelopmental impairment in monochorionic twins treated with amnioreduction versus laser surgery for twin-twin transfusion syndrome. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A systematic review and meta-analysis of studies on cerebral injury and long-term impairment after amnioreduction versus laser surgery were conducted. Odds ratios (OR) with their 95% confidence interval (CI) were computed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Electronic and manual search identified 63 references. Five studies were included for analysis. We found an ample seven-fold higher risk of severe cerebral injury in live-born children treated with amnioreduction compared to laser (OR 7.69, 95% CI 2.78-20.0, p = 0.00). In children surviving the neonatal period, the odds were three-times higher following amnioreduction (OR 3.23, 95% CI 1.45-7.14, p = 0.00). Although not significant, monochorionic twins treated with amnioreduction had higher odds of periventricular leukomalacia and intraventricular hemorrhage (OR 2.08, 95% CI 0.86-5.00, p = 0.10 and OR 3.56, 95% CI 0.82-14.29, p = 0.09). Unfortunately, there were insufficient long-term outcome data available to estimate the odds of neurodevelopmental impairment. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Amnioreduction is associated with an increased risk of severe cerebral injury compared to laser surgery in twin-twin transfusion syndrome. Our study highlights a lack of studies focusing on long-term neurodevelopmental outcome. Follow-up into childhood is indispensable to determine outcome in terms of motor, cognitive and socioemotional development.<\/jats:p>","DOI":"10.1159\/000341814","type":"journal-article","created":{"date-parts":[[2012,8,28]],"date-time":"2012-08-28T07:42:34Z","timestamp":1346139754000},"page":"81-89","source":"Crossref","is-referenced-by-count":51,"title":["Cerebral Injury and Neurodevelopmental Impairment after Amnioreduction versus Laser Surgery in Twin-Twin Transfusion Syndrome: A Systematic Review and Meta-Analysis"],"prefix":"10.1159","volume":"33","author":[{"given":"Jeanine M.M.","family":"van Klink","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hendrik M.","family":"Koopman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erik W.","family":"van Zwet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dick","family":"Oepkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frans J.","family":"Walther","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Lopriore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,8,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jp.7200292"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD002073.pub2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2011.07.006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2009.06.005"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-4328(05)80189-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136\/adc.56.12.900"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.327.7414.557"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0197-2456(86)90046-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.05.034"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.09.043"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.01.036"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa032597"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.08.054"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2009.05.036"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(99)70278-4"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1067\/mob.2003.292"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1375\/183242706777591371"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/341814","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/341814","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:41:25Z","timestamp":1745433685000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000341814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,24]]},"references-count":18,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,3,1]]},"published-print":{"date-parts":[[2013,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000341814","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"value":"1015-3837","type":"print"},{"value":"1421-9964","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,24]]}}}