{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T11:52:19Z","timestamp":1782993139774,"version":"3.54.5"},"reference-count":10,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2012]]},"abstract":"<b><i>Aims:<\/i><\/b> The aim of this study was to evaluate the proportion of patients with treated myasthenia gravis (MG) who present with dyspnea not related to MG. <b><i>Methods:<\/i><\/b> We analyzed the files of 63 consecutive adult patients with treated MG and persistent dyspnea who had been referred to our Pulmonary Function Test (PFT) Department between 2000 and 2010. <b><i>Results:<\/i><\/b> We observed that asthma was the first cause of MG-unrelated dyspnea in MG patients, with 9 patients (14%) presenting with asthma-related PFT abnormalities. Six patients had asthma for several years before developing MG, and 3 patients (4%) developed asthma a few months after MG was diagnosed, suggesting a non-coincidental association between the two conditions. In all 3 cases, asthma appeared in elderly patients with severe late-onset AchR-Ab- positive MG, treated with pyridostigmine and corticosteroids and\/or intravenous immunoglobulins. In all 3 patients, \u03b2<sub>2<\/sub>-adrenergic agonist treatment allowed only partial control of dyspnea. In one case, respiratory symptoms were alleviated when pyridostigmine dosage was reduced. <b><i>Conclusions:<\/i><\/b> Patients with treated MG and persistent dyspnea should be investigated for asthma using PFT before being diagnosed with refractory MG. If asthma is diagnosed, a bronchodilator treatment should be instituted and a reduction in pyridostigmine dosage should be proposed.<\/jats:p>","DOI":"10.1159\/000341834","type":"journal-article","created":{"date-parts":[[2012,10,9]],"date-time":"2012-10-09T08:08:42Z","timestamp":1349770122000},"page":"300-303","source":"Crossref","is-referenced-by-count":5,"title":["Asthma as a Cause of Persistent Dyspnea in Treated Myasthenia Gravis Patients"],"prefix":"10.1159","volume":"68","author":[{"given":"Andoni","family":"Echaniz-Laguna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Pistea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Philippi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irina","family":"Enache","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monique","family":"Oswald-Mammosser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00e9rome","family":"De S\u00e8ze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Charloux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,10,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2809%2970063-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.95.08071130"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0404.2010.01369.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jns.2004.06.018"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2876%2990938-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-5728%2898%2900159-3"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jns.2011.05.028"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1158%2F1078-0432.CCR-04-0735"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fni.1892"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1378%2Fchest.103.6.1755"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/341834","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/341834","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/341834","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:41:31Z","timestamp":1745433691000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000341834"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":10,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,11,1]]},"published-print":{"date-parts":[[2012,11,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000341834","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}