{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:36:32Z","timestamp":1783485392159,"version":"3.55.0"},"reference-count":13,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T00:00:00Z","timestamp":1347321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,9,11]],"date-time":"2012-09-11T00:00:00Z","timestamp":1347321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Skin Pharmacol Physiol"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose of the Study:&lt;\/i&gt;&lt;\/b&gt; To investigate the role of paraoxonase 1 (PON1) and vitamin E in the pathogenesis of some autoimmune diseases, and to correlate their levels with the disease activity. &lt;b&gt;&lt;i&gt;Procedures:&lt;\/i&gt;&lt;\/b&gt; This randomized case control study was performed on 60 subjects: 45 patients [suffering from psoriasis, vitiligo and alopecia areata (AA) 15 patients each group] and 15 healthy controls. Venous blood and tissue biopsy were collected from each subject to estimate the levels of vitamin E and PON1. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; All patients showed significantly lower levels of both PON1 and vitamin E in tissue and serum than the controls (p &lt; 0.001). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; An association between oxidative stress and pathogenesis of these autoimmune diseases is identified. Attenuation of oxidative stress might be a relevant therapeutic approach and it would be useful to recommend additional drugs with antioxidant effects in the treatment of these conditions.<\/jats:p>","DOI":"10.1159\/000342124","type":"journal-article","created":{"date-parts":[[2012,9,17]],"date-time":"2012-09-17T07:08:29Z","timestamp":1347865709000},"page":"2-7","source":"Crossref","is-referenced-by-count":41,"title":["The Antioxidant Role of Paraoxonase 1 and Vitamin E in Three Autoimmune Diseases"],"prefix":"10.1159","volume":"26","author":[{"given":"R.","family":"Ramadan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Tawdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Abdel Hay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Rashed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Tawfik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,9,11]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1996.tb07607.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.2010.03799.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fcbf.1553"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2FBF03180575"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.tox.2006.10.014"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0306-9877%2891%2990238-T"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0749.1998.tb00714.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cbi.2005.12.009"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000250839"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.125.2.235"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.135.4.407"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2F1099-0844%28200009%2918%3A3%3C169%3A%3AAID-CBF870%3E3.0.CO%3B2-T"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0749.1994.tb00034.x"}],"container-title":["Skin Pharmacology and Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342124","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342124","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:44:18Z","timestamp":1745433858000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000342124"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,9,11]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,12,1]]},"published-print":{"date-parts":[[2012,12,18]]}},"URL":"https:\/\/doi.org\/10.1159\/000342124","archive":["Portico"],"relation":{},"ISSN":["1660-5527","1660-5535"],"issn-type":[{"value":"1660-5527","type":"print"},{"value":"1660-5535","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,9,11]]}}}