{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T17:56:52Z","timestamp":1785002212254,"version":"3.55.0"},"reference-count":27,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Studies examining comorbidities among psoriasis patients with varying disease severities measured by body surface area (BSA) are lacking. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To examine the association between psoriasis severity and comorbid conditions, including rheumatologic, cardiovascular and other immune-mediated diseases. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; From 2003 to 2011, the National Psoriasis Foundation conducted surveys among 5,604 psoriasis patients. The combined surveys represented the largest study to date that used BSA as a direct measure of psoriasis severity for comorbidity assessment. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Over 86% of psoriatic arthritis (PsA) patients reported presenting with psoriasis prior to PsA; the diagnosis of psoriasis preceded that of PsA by a mean period of 14.6 years. Compared to those with mild psoriasis, patients with moderate-to-severe psoriasis had significantly increased adjusted odds of PsA (moderate: odds ratio, OR: 1.21, 95% confidence interval, CI: 1.04\u20131.41; severe: OR: 2.32, 95% CI: 1.98\u20132.70). Patients with severe psoriasis had increased adjusted odds of diabetes (OR: 1.5, 95% CI: 1.08\u20132.08) and cardiovascular disease (OR: 1.5, 95% CI: 1.01\u20132.24) compared to those with mild-to-moderate psoriasis. Odds of rheumatoid arthritis, ankylosing spondylitis, lupus, Crohn\u2019s disease and multiple sclerosis were not significantly increased in patients with severe psoriasis. &lt;b&gt;&lt;i&gt;Conclusion: &lt;\/i&gt;&lt;\/b&gt;Compared to those with mild-to-moderate psoriasis, patients with severe psoriasis are at increased odds of PsA, diabetes and cardiovascular diseases.<\/jats:p>","DOI":"10.1159\/000342180","type":"journal-article","created":{"date-parts":[[2012,10,30]],"date-time":"2012-10-30T11:04:53Z","timestamp":1351595093000},"page":"121-126","source":"Crossref","is-referenced-by-count":73,"title":["Psoriasis Comorbidities: Results from the National Psoriasis Foundation Surveys 2003 to 2011"],"prefix":"10.1159","volume":"225","author":[{"given":"April W.","family":"Armstrong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clayton","family":"Schupp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruce","family":"Bebo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,10,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1468-3083.2001.00192.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1529-8019.2010.01304.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjmed.2009.06.021"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.296.14.1735"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2796.2010.02310.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fehp567"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000330560"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2230.1994.tb01167.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.3899%2Fjrheum.101117"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3899%2Fjrheum.101118"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.3899%2Fjrheum.101119"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2005.03.046"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Fard.2009.125476"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001%2Farchdermatol.2009.48"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.2008.02636.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2008.08814.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2006.09.017"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fehn387"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.biocel.2005.11.008"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.3899%2Fjrheum.090822"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4632.2009.04075.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2010.01.050"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.296.14.1735"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2796.2008.01945.x"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0625.2011.01308.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra0804595"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jdermsci.2011.04.007"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342180","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342180","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:44:41Z","timestamp":1745433881000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000342180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,11,1]]},"published-print":{"date-parts":[[2012,11,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000342180","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}