{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:20:18Z","timestamp":1790814018118,"version":"4.1.0"},"reference-count":22,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,11,24]],"date-time":"2012-11-24T00:00:00Z","timestamp":1353715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,11,24]],"date-time":"2012-11-24T00:00:00Z","timestamp":1353715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background:<\/i><\/b> There is no consensus or evidence as to whether a neuromuscular blocking agent should be used during the initial resuscitation of infants with congenital diaphragmatic hernia (CDH) in the labour ward. <b><i>Objective:<\/i><\/b> To determine if administration of a neuromuscular blocking agent affected the lung function of infants with CDH during their initial resuscitation in the labour ward. <b><i>Methods:<\/i><\/b> Fifteen infants with CDH were studied (median gestational age 38 weeks, range 34\u201341; birth weight 2,790 g, range 1,780\u20133,976). Six infants had undergone feto-endotracheal occlusion (FETO). Flow, airway pressure, tidal volume and dynamic lung compliance changes were recorded using a respiratory function monitor (NM3, Respironics). Twenty inflations immediately before, immediately after and 5 min after administration of a neuromuscular blocking agent (pancuronium bromide) were analysed. <b><i>Results:<\/i><\/b> The median dynamic lung compliance of the 15 infants was 0.22 ml\/cm H<sub>2<\/sub>O\/kg (range 0.1\u20130.4) before and 0.16 ml\/cm H<sub>2<\/sub>O\/kg (range 0.1\u20130.3) immediately after pancuronium bromide administration (p < 0.001) and remained at a similar low level 5 min after pancuronium bromide administration. The FETO compared to the non-FETO infants had a lower median dynamic compliance both before (p < 0.0001) and 5 min after pancuronium administration (p < 0.001) and required significantly longer durations of ventilation (p = 0.004), supplementary oxygen (p = 0.003) and hospitalisation (p = 0.007). <b><i>Conclusions:<\/i><\/b> Infants with CDH, particularly those who have undergone FETO, have a low lung compliance at birth, and this is further reduced by administration of a neuromuscular blocking agent.<\/jats:p>","DOI":"10.1159\/000342332","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T07:59:49Z","timestamp":1353916789000},"page":"112-117","source":"Crossref","is-referenced-by-count":20,"title":["Neuromuscular Blockade and Lung Function during Resuscitation of Infants with Congenital Diaphragmatic Hernia"],"prefix":"10.1159","volume":"103","author":[{"given":"Vadivelam","family":"Murthy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walton","family":"D\u2019Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kypros","family":"Nicolaides","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Davenport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grenville","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony D.","family":"Milner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morag","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Greenough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F00008480-200208000-00022"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2007-3282"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00383-008-2257-y"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000316974"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000319064"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000320622"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1053%2Fjpsu.2002.30834"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2884%2980563-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.99.14235799"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2884%2990177-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1152%2Fajplung.00294.2010"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2011.03.025"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajog.2006.04.004"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2F0378-3782%2890%2990025-E"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1442-200X.2007.02405.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00000542-200610000-00010"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00134-009-1564-7"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1371%2Fjournal.pmed.0040237"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1183%2F09031936.00058009"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3468%2897%2990502-9"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.59.11.1046"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.60.5.496-a"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342332","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342332","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:46:20Z","timestamp":1745433980000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000342332"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,24]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,1]]},"published-print":{"date-parts":[[2013,2,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000342332","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,24]]}}}