{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:35:19Z","timestamp":1745469319896,"version":"3.40.4"},"reference-count":30,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; The effects of cigarette smoke (CS) on cyclosporine (CsA)-induced nephrotoxicity are poorly studied. This study aims to assess the effects of previous exposure to CS on CsA nephrotoxicity. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Rats were either exposed to CS or sham (S) procedures for 10 min twice a day for 20 weeks. From the 16th to the 20th week, they received a low-salt diet. Beginning with the 17th week, they were given 2.5 mg\/day CsA or vehicle (VH) for 3 weeks. The final groups were VH\/CS, CsA\/CS, VH\/S, and CsA\/S. On day 141, glomerular filtration rate (GFR), renal blood flow (RBF), renal vascular resistance (RVR), tubulointerstitial fibrosis, and CsA blood levels were measured and immunohistochemistry was analyzed for renal \u03b1-smooth muscle actin (SMA), nitrotyrosine, and vimentin. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; CsA decrease in GFR was enhanced by CS exposure. CsA associated with CS induced higher periglomerular \u03b1-SMA and renal nitrotyrosine expression. CsA decreased RBF, but increased RVR, tubulointerstitial fibrosis, and \u03b1-SMA and renal vimentin expression. These changes and the CsA blood levels were not affected by CS exposure. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; CS aggravated the CsA-induced impairment of GFR and CS associated with CsA caused the development of periglomerular structural lesions and oxidative stress in a rat model of CsA nephrotoxicity.<\/jats:p>","DOI":"10.1159\/000342337","type":"journal-article","created":{"date-parts":[[2012,9,27]],"date-time":"2012-09-27T00:35:33Z","timestamp":1348706133000},"page":"334-341","source":"Crossref","is-referenced-by-count":3,"title":["Previous Exposure to Cigarette Smoke Aggravates Experimental Cyclosporine-Induced Nephrotoxicity"],"prefix":"10.1159","volume":"36","author":[{"given":"Sueli A.","family":"Alves","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla P.","family":"Carlos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gl\u00f3ria E.F.","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra M.","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus A.M.","family":"Luz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael P.S.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rael L.","family":"Matimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Terezila M.","family":"Coimbra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel A.","family":"Burdmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,9,26]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfm275"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfm764"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.03740907"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.00700111"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2458-10-731"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2FHJH.0b013e328332038c"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.00070109"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2010.02.351"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2009.10.058"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000328903"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.healun.2006.09.023"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-6143.2011.03701.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.transproceed.2011.01.045"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2002.00382.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000093461.36097.D5"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0270-9295%2803%2900090-1"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02893379"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-200106270-00009"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1432-2277.2007.00621.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1681.2008.04983.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159%2F000163593"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097%2F00004872-200404000-00013"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.29.8.1656"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.vph.2010.03.006"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00293.2010"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1582-4934.2008.00518.x"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1097%2FTP.0b013e3181da0587"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00125-001-0744-y"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000032422.81130.68"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2007.01.014"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342337","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342337","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:46:23Z","timestamp":1745433983000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000342337"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,10,1]]},"published-print":{"date-parts":[[2012,10,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000342337","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"type":"print","value":"0250-8095"},{"type":"electronic","value":"1421-9670"}],"subject":[],"published":{"date-parts":[[2012]]}}}