{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T14:37:07Z","timestamp":1788187027287,"version":"build-2803163510"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Erythroderma is a rare skin disorder and studies on its causes and prognosis are rare in the literature. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; We reviewed the clinical, laboratory and biopsy materials of 260 patients diagnosed with erythroderma who were treated in our department over an 11-year period. Patients were followed up to better understand the evolution of erythroderma. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This study was performed at our hospital between January 2001 and 2012 and included 260 patients with erythroderma. We recorded epidemio-clinical, biological and histological data, treatments and outcomes. Clinical-histological correlation was analyzed. Overall survival and relapse-free survival for a limited number of etiologies were described using Kaplan-Meier estimates. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The mean age at onset in this study was 52.57 \u00b1 17.94 (SD) years (range 13\u201387), with a male-to-female ratio of 3:1. Acute onset was present in 15.38% of patients. Clinical findings were dominated by pruritus (87.69%), fever (40%), edema (37.69%), chills (31.15%), nail changes (29.62%), weakness (19.23%), lymphadenopathy (19.23%), weight loss (14.62%) and islands of normal skin (13.46%). Skin biopsies revealed the cause in 55.56% (65\/117) of the patients. The most common causative factors were pre-existing dermatoses (70.77%), followed by idiopathic causes (14.23%), drug reactions (12.69%) and malignancies (2.31%). Among the pre-existing dermatoses, psoriasis was the most common etiology (143\/260, 55%). In the drug-induced group, carbamazepine was the most frequently implicated drug in our study (33.33%). Chinese traditional herbal medicines are among the causes of drug-induced erythroderma as well. We also found that Langerhans cell histiocytosis, tongue cancer, hypereosinophilic syndrome, bullous pemphigoid and dermatomyositis could be causes of erythroderma. From our follow-up study, 39 (31.2%) of the 125 patients from whom information was available had relapsed. The patients with idiopathic erythroderma had a higher relapse rate. Of the 5 patients who died, 4 deaths were directly related to erythroderma. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Most of the clinical features of erythroderma are unspecific with few cause-orienting clues. Although numerous laboratory values were abnormal, most findings were nondiagnostic and were related to the inflammatory process, except for skin biopsy. Our study had a high percentage of erythroderma secondary to pre-existing dermatoses and a low percentage of malignancy patients. Repeated evaluations, close follow-up and biopsy are recommended.<\/jats:p>","DOI":"10.1159\/000342365","type":"journal-article","created":{"date-parts":[[2012,10,2]],"date-time":"2012-10-02T07:02:21Z","timestamp":1349161341000},"page":"154-162","source":"Crossref","is-referenced-by-count":62,"title":["Erythroderma: A Clinical and Prognostic Study"],"prefix":"10.1159","volume":"225","author":[{"given":"Jun","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"He-Yi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,10,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-4362.1998.00228.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2883%2980013-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4632.2004.02100.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4632.2004.01975.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.1994.01690120039004"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0560.1993.tb00660.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0733-8635%2805%2970189-3"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00007611-198610000-00005"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0560.1994.tb00283.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000320772"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000338572"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2808%2980580-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-5945-5-5"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.1973.01620270014003"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2888%2970139-5"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1590%2FS0034-89101995000300004"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-4362.1999.00846.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2896%2990496-X"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.2009.03526.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159%2F000249271"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342365","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342365","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:46:35Z","timestamp":1745433995000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000342365"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2012,11,1]]},"published-print":{"date-parts":[[2012,11,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000342365","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}