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There has been no systematic analysis of which combinations are frequent\/infrequent and whether two concurrent diseases in one patient are clonally related or represent independent diseases. We therefore characterised a series of cases from our own archive (n = 65) and collected a large number of previously reported cases of patients in whom myeloid and lymphoid\/plasmacytoid neoplasms co-occurred (n = 185). The most frequent combination was Philadelphia chromosome-negative myeloproliferative neoplasm with concurrent B cell chronic lymphocytic leukaemia, accounting for approximately 50% of double-disease patients. We compared the quantity of unsorted bone marrow cell-derived JAK2&lt;sup&gt;V617F&lt;\/sup&gt; and KIT&lt;sup&gt;D816V&lt;\/sup&gt; alleles with the quantity of the lymphoid\/plasmacytoid compartment and analysed a subfraction of cases with fluorescence in situ hybridisation. Although a common aberrant progenitor has been reported in some cases in the literature, we found evidence of two independent chronic-stage myeloid and lymphoid\/plasmacytoid neoplasms.<\/jats:p>","DOI":"10.1159\/000342484","type":"journal-article","created":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T13:57:18Z","timestamp":1356098238000},"page":"187-196","source":"Crossref","is-referenced-by-count":15,"title":["Simultaneous and Sequential Concurrent Myeloproliferative and Lymphoproliferative 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