{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:35:24Z","timestamp":1745469324772,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2012,10,3]],"date-time":"2012-10-03T00:00:00Z","timestamp":1349222400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,10,3]],"date-time":"2012-10-03T00:00:00Z","timestamp":1349222400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background:<\/i><\/b> Insufficiency of the pulmonary surfactant system is the primary cause of respiratory distress syndrome (RDS) in preterm infants. Genetic factors, including specific single-nucleotide polymorphisms in the genetic components of surfactant protein A (SP-A1 and SP-A2), affect protein structure and function, as well as risk of RDS. <b><i>Objective:<\/i><\/b> We investigated the association between variations in SP-A genotypes and RDS within the genetically homogeneous Korean population. <b><i>Methods:<\/i><\/b> We used TaqMan\u00ae real-time polymerase chain reaction technology to assess nine single-nucleotide polymorphisms of SP-A in 261 full-term and 152 preterm infants. Among the preterm infants, 76 infants with RDS were matched with 76 control infants with respect to gestation, use of antenatal steroids and gender. <b><i>Results:<\/i><\/b> The SP-A2 1A&#8304; variant and the homozygous 1A&#8304;\/1A&#8304; genotype were associated with protection from RDS (OR 0.31, 95% CI 0.13\u20130.78). In addition, the 1A<sup>1<\/sup> carrier genotype (containing one copy of the 1A<sup>1<\/sup> variant) was associated with increased risk of RDS (OR 2.42, 95% CI 1.06\u20135.52). The significance of these results is that the association of patterns with RDS was opposite to the findings of previous research with Finnish and North American study populations. <b><i>Conclusions:<\/i><\/b> We have identified associations between specific variants of the SP-A genes and RDS risk in the Korean preterm study population. Our data strongly support SP-A as a candidate gene for susceptibility to RDS, and reveal the dissimilarity of the associated risk\/protective genetic variants between different ethnic study populations.<\/jats:p>","DOI":"10.1159\/000342498","type":"journal-article","created":{"date-parts":[[2012,10,3]],"date-time":"2012-10-03T06:52:30Z","timestamp":1349247150000},"page":"44-47","source":"Crossref","is-referenced-by-count":11,"title":["Surfactant Protein A Associated with Respiratory Distress Syndrome in Korean Preterm Infants: Evidence of Ethnic Difference"],"prefix":"10.1159","volume":"103","author":[{"given":"Heui Seung","family":"Jo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Il","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoon Hwan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beyong Il","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Hwan","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,10,3]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1159%2F000101345"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.2741%2F3935"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.2174%2F092986706778773112"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1074%2Fjbc.M109.046243"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1086%2F302906"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1080%2F07853890310006389"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1034%2Fj.1399-0004.2001.600303.x"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1111%2Fj.1651-2227.2007.00319.x"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1186%2F1471-2156-4-13"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1159%2F000297773"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1159%2F000322004"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1034%2Fj.1399-0039.2003.00038.x"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1159%2F000326619"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342498","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342498","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:48:18Z","timestamp":1745434098000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000342498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,10,3]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2012,12,1]]},"published-print":{"date-parts":[[2012,12,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000342498","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5123992","asserted-by":"subject"}]},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2012,10,3]]}}}