{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:11:58Z","timestamp":1787868718538,"version":"build-2784847793"},"reference-count":19,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; To date, there is no agreement about the frequency or the features of thyroid abnormalities in McCune-Albright syndrome (MAS). The aim of our study was to detect thyroid abnormalities in a cohort of MAS children and adolescents and to give indications for their treatment and follow-up. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; In 36 patients, 22 females and 14 males, thyroid function and sonographic features of thyroid were evaluated every 6\u201312 months. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Three males and 1 female had hyperthyroidism: 2 with nodular, 2 with diffuse goiters. They were treated with methimazole (0.2\u20130.5 mg\/kg\/day) with good clinical and biochemical responses. The remaining 32 patients were euthyroid, even if 7 displayed sonographic alterations, of whom 5 had nodular goiter with nodules &gt;1 cm, and 2 micronodular goiter. Fine-needle aspiration biopsy was performed in 2 patients with nodules &gt;1 cm, 1 showing hemorrhagic nodule and 1 colloid cystic nodule. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Prevalence of thyroid alterations in the studied MAS series was 31%. 64% of 11 patients with thyroid alterations had nodular goiters, with nodules &gt;1 cm. As the onset of thyroid disease ranged from 1 to 20 years, a strict monitoring of thyroid function is recommended every 6 months. Satisfactory treatment can be obtained and maintained with antithyroid drugs.<\/jats:p>","DOI":"10.1159\/000342641","type":"journal-article","created":{"date-parts":[[2012,9,20]],"date-time":"2012-09-20T08:27:18Z","timestamp":1348129638000},"page":"151-157","source":"Crossref","is-referenced-by-count":54,"title":["Thyroid Abnormalities in Children and Adolescents with McCune-Albright Syndrome"],"prefix":"10.1159","volume":"78","author":[{"given":"D.","family":"Tessaris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Corrias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Matarazzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"De Sanctis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Wasniewska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.F.","family":"Messina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.C.","family":"Vigone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Lala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,9,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2805%2980943-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-71-6-1596"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1089%2Fthy.1997.7.433"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1590%2FS0004-27302008000300017"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2001-11271"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2002-021642"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-0029-1211263"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0929-693X%2810%2970014-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199112123252403"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.91.22.10488"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9343%2891%2990153-O"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1148%2Frg.273065038"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210%2Fme.16.5.903"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS1470-2045%2808%2970132-3"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2011-1469"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2007-0641"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F00009957-200305000-00001"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2F00000441-200607000-00012"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00402-008-0669-8"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342641","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342641","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:48:56Z","timestamp":1745434136000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000342641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2012,10,1]]},"published-print":{"date-parts":[[2012,10,24]]}},"URL":"https:\/\/doi.org\/10.1159\/000342641","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}