{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:09:33Z","timestamp":1773274173523,"version":"3.50.1"},"reference-count":21,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T00:00:00Z","timestamp":1352851200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"},{"start":{"date-parts":[[2012,11,14]],"date-time":"2012-11-14T00:00:00Z","timestamp":1352851200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/3.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Treatment with radioiodine for Graves\u2019 disease regularly increases the level of antithyroid antibodies, and transplacental passage of stimulating thyrotropin receptor antibodies (TRAb) may cause fetal hyperthyroidism. &lt;b&gt;&lt;i&gt;Case presentation:&lt;\/i&gt;&lt;\/b&gt; A 21-year-old woman with Graves\u2019 disease received radioiodine treatment to avoid use of antithyroid drugs in pregnancy. She became pregnant 4 months later and was euthyroid during pregnancy. In gestational week (GW) 33, she was admitted with an increased fetal heart rate of 176\u2013180 beats\/min. Fetal echocardiography indicated cardiac decompensation. The neonate had severe hyperthyroidism (free thyroxine &gt;100 pmol\/l, nv 12.0\u201322.0), cardiac insufficiency, insufficient weight gain, goiter and considerably accelerated skeletal age. In the mother and neonate, TRAb was &gt;40 IU\/l (nv &lt;1.0), indicating transplacental passage of stimulating antibodies. After delivery, TRAb remained &gt;40 IU\/l in the woman, and 18 months later she underwent total thyroidectomy with subsequent decline in TRAb. In her next pregnancy, TRAb fluctuated between 38 and 17 IU\/l, and repeated fetal ultrasound showed no goiter or sign of hyperthyroidism. In cord blood, TRAb was 10.9 IU\/l, and the neonate had normal thyroid hormone levels. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; This case report illustrates the impact of maternal TRAb level for neonatal outcome in two successive pregnancies.<\/jats:p>","DOI":"10.1159\/000342644","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T08:16:37Z","timestamp":1353053797000},"page":"39-43","source":"Crossref","is-referenced-by-count":6,"title":["Impact of Thyrotropin Receptor Antibody Levels on Fetal Development in Two Successive Pregnancies in a Woman with Graves\u2019 Disease"],"prefix":"10.1159","volume":"79","author":[{"given":"Marit R.","family":"Bj\u00f8rgaas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanne","family":"Farstad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sverre C.","family":"Christiansen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harm-Gerd K.","family":"Blaas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,11,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1089%2Fthy.2011.0087"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000092454"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.1390584"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0889-8529%2805%2970307-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1530%2FEJE-07-0450"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1507%2Fendocrj.K10E-123"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-0028-1110089"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1515%2FJPEM.2007.20.4.535"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2004-2555"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1530%2FEJE-08-0663"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1991.tb11945.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080%2F08916930701619466"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1507%2Fendocrj.K06-196"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000329187"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1089%2Fthy.2005.15.1373"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2009-3244"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2Fbjs.8660"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1507%2Fendocrj.50.595"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2Fs12020-011-9559-x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMcp0803050"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.3109%2F09513590.2010.491166"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342644","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342644","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342644","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:48:56Z","timestamp":1745434136000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000342644"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,14]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,2,1]]},"published-print":{"date-parts":[[2013,2,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000342644","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,14]]}}}