{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:06:34Z","timestamp":1787166394777,"version":"build-2736575974"},"reference-count":38,"publisher":"Bioscientifica","issue":"4","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":4891,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Objective: To assess the impact on cord blood (CB) thyroglobulin (Tg) of early iodine supplementation during pregnancy. Methods: A total of 111 healthy pregnant women with normal thyroid function were included in a prospective randomized study and divided into two groups with (150 \u00b5g\/day) or without iodine supplementation started during the first trimester. Maternal smoking was assessed qualitatively by self-reported statements and quantitatively by cotininuria. Exhaustive thyroid tests were performed at delivery in the mother and in CB. Results: Third-trimester ioduria documented compliance with iodine supplementation (160 vs. 76 \u00b5g\/l in controls). CB Tg was not different between the iodine and control groups (median 77 vs. 79.5 ng\/ml, respectively) and did not correlate with maternal ioduria. CB Tg was higher in newborns from smoking mothers (114 vs. 64.7 ng\/ml) and correlated with self-reported smoking status more than with maternal cotininuria. Nonsmokers had no difference in CB Tg whether they took iodine supplementation or not, as opposed to smokers, who tended to benefit from supplementation. Conclusions: Iodine supplementation does not significantly impact CB Tg in healthy nonsmoker pregnant women selected for normal thyroid function, as opposed to maternal smoking. CB Tg appears to be a marker of in utero tobacco exposure. In areas of mild iodine deficiency, iodine supplementation could especially benefit the fetuses of smokers.<\/jats:p>","DOI":"10.1159\/000342915","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T03:16:37Z","timestamp":1353035797000},"page":"264-273","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":6,"title":["Relative Impact of Iodine Supplementation and Maternal Smoking on Cord Blood Thyroglobulin in Pregnant Women with Normal Thyroid Function"],"prefix":"10.1530","volume":"1","author":[{"given":"Sylvie","family":"Hi\u00e9ronimus","sequence":"first","affiliation":[{"name":"1Departments of Endocrinology, Diabetology and Reproductive Medicine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Ferrari","sequence":"additional","affiliation":[{"name":"2Departments of Biochemistry, University Hospital of Nice"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jocelyn","family":"Gal","sequence":"additional","affiliation":[{"name":"4Department of Biostatistics, University of Nice"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Berthier","sequence":"additional","affiliation":[{"name":"4Department of Biostatistics, University of Nice"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"St\u00e9phane","family":"Azoulay","sequence":"additional","affiliation":[{"name":"5Institute of Chemistry, UMR 6001, University of Nice-Sophia-Antipolis"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9","family":"Bongain","sequence":"additional","affiliation":[{"name":"3Gynaecology and Obstetrics, University Hospital of Nice"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"F\u00e9nichel","sequence":"additional","affiliation":[{"name":"1Departments of Endocrinology, Diabetology and Reproductive Medicine"},{"name":"6Institut National de la Recherche M\u00e9dicale, UMR U895, University Nice-Sophia-Antipolis, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7oise","family":"Brucker-Davis","sequence":"additional","affiliation":[{"name":"1Departments of Endocrinology, Diabetology and Reproductive Medicine"},{"name":"6Institut National de la Recherche M\u00e9dicale, UMR U895, University Nice-Sophia-Antipolis, Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2012,9,26]]},"reference":[{"key":"2026070712423157800_ref1","doi-asserted-by":"crossref","unstructured":"Zimmermann MB: Iodine deficiency. 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