{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T12:22:03Z","timestamp":1775218923928,"version":"3.50.1"},"reference-count":20,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2012]]},"abstract":"<b><i>Background:<\/i><\/b> Flubendazole (FLBZ) is a broad-spectrum benzimidazole anthelmintic compound. The parent FLBZ is metabolized to its reduced (R-FLBZ) and hydrolyzed (H- FLBZ) metabolites. There are no data on the potential nematodicidal activity of R-FLBZ, the main plasma metabolite found in sheep and mice. The goal of the current work was to assess the efficacy of FLBZ and R-FLBZ against <i>Trichinella spiralis <\/i>in a mouse model. <b><i>Methods:<\/i><\/b> Both compounds were administered to Balb\/c mice<b> <\/b>infected with <i>T. spiralis<\/i> as either a cyclodextrin aqueous solution or as a carboxymethylcellulose suspension. Treatments were performed orally (5 mg\/kg) at 1 day after infection with <i>T. spiralis<\/i>. The efficacy of the treatments was assessed at day 6 after infection. <b><i>Results:<\/i><\/b> While the efficacy obtained for FLBZ and R-FLBZ administered as a solution was 94 and 98%, respectively, the efficacies obtained after the treatment with FLBZ suspensions were 38% (FLBZ) and 64% (R-FLBZ). <b><i>Conclusion: <\/i><\/b>Under the current experimental conditions, a high nematodicidal efficacy of both FLBZ and R-FLBZ administered as solution preparations was observed.<\/jats:p>","DOI":"10.1159\/000342924","type":"journal-article","created":{"date-parts":[[2012,10,19]],"date-time":"2012-10-19T15:40:51Z","timestamp":1350661251000},"page":"295-298","source":"Crossref","is-referenced-by-count":6,"title":["Nematodicidal Activity of Flubendazole and Its Reduced Metabolite on a Murine Model of <b><i>Trichinella spiralis <\/i><\/b>Infection"],"prefix":"10.1159","volume":"58","author":[{"given":"Luc\u00eda","family":"Urbizu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandra","family":"Confalonieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergio","family":"S\u00e1nchez Bruni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Lanusse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luis Ignacio","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.parint.2009.07.006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000290172"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000315066"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2885.1990.tb00773.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109%2F03602539308993977"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1128%2FAAC.05105-11"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000316827"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0169-4758%2890%2990228-V"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2885.1984.tb00886.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2885.1999.00194.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-4017%2800%2900320-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0169-4758%2890%2990227-U"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-4894%2891%2990023-P"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0020-7519%2897%2900104-5"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1021%2Fjf001094z"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2885.2004.00616.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.vetpar.2009.05.014"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0020-7519%2897%2900052-0"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.exppara.2005.12.004"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-5173%2802%2900559-8"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342924","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342924","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/342924","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:19:56Z","timestamp":1745432396000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000342924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":20,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2012,11,1]]},"published-print":{"date-parts":[[2012,11,29]]}},"URL":"https:\/\/doi.org\/10.1159\/000342924","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}