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Obese people with a normal thyroid gland tend to have activation of the hypothalamic-pituitary-thyroid axis with higher serum TSH and thyroid hormones in serum. On the other hand, small differences in thyroid function are associated with up to 5 kg difference in body weight. The weight loss after therapy of overt hypothyroidism is caused by excretion of water bound in tissues (myxoedema). Many patients treated for hyperthyroidism experience a gain of more weight than they lost during the active phase of the disease. The mechanism for this excessive weight gain has not been fully elucidated. New studies on the relation between L-T&amp;lt;sub&amp;gt;3&amp;lt;\/sub&amp;gt; therapy and weight control are discussed. The interaction between weight control and therapy of thyroid disease is important to many patients and it should be studied in more detail.<\/jats:p>","DOI":"10.1159\/000342994","type":"journal-article","created":{"date-parts":[[2012,10,19]],"date-time":"2012-10-19T11:41:22Z","timestamp":1350646882000},"page":"159-167","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":153,"title":["Thyroid Function and Obesity"],"prefix":"10.1530","volume":"1","author":[{"given":"Peter","family":"Laurberg","sequence":"first","affiliation":[{"name":"1Department of Endocrinology, Aalborg Hospital, Aalborg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils","family":"Knudsen","sequence":"additional","affiliation":[{"name":"2Medical Clinic I, Bispebjerg Hospital, Copenhagen, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stig","family":"Andersen","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Aalborg Hospital, Aalborg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan","family":"Carl\u00e9","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Aalborg Hospital, Aalborg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inge B\u00fclow","family":"Pedersen","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Aalborg Hospital, Aalborg"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesper","family":"Karmisholt","sequence":"additional","affiliation":[{"name":"1Department of Endocrinology, Aalborg Hospital, Aalborg"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2012,9,21]]},"reference":[{"key":"2026070711500441500_ref1","doi-asserted-by":"crossref","unstructured":"Caballero B: The global epidemic of obesity: an overview. 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