{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T19:57:18Z","timestamp":1775591838485,"version":"3.50.1"},"reference-count":17,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,11,24]],"date-time":"2012-11-24T00:00:00Z","timestamp":1353715200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,11,24]],"date-time":"2012-11-24T00:00:00Z","timestamp":1353715200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background:<\/i><\/b> Earlier and more accurate identification of a high-risk group of preterm infants that are likely to develop a hemodynamically significant patent ductus arteriosus (hsPDA) would allow specific targeting of early treatment and thus possibly minimize the morbidity and mortality associated with a PDA in extremely low birth weight (ELBW) infants. <b><i>Objective:<\/i><\/b> To investigate the predictability of B-type natriuretic peptide (BNP) for early targeted treatment of hsPDA in ELBW infants. <b><i>Methods:<\/i><\/b> 73 ELBW infants that underwent echocardiographic evaluation and plasma BNP measurement after birth were enrolled. 31 infants developed hsPDA (HsPDA group) and 42 infants did not develop hsPDA (nPDA group). <b><i>Results:<\/i><\/b> BNP levels of the HsPDA group were significantly higher than those of the nPDA group at 24 h of age (921 [318\u20132,133] vs. 152 [91\u2013450] pg\/ml) but not different at 12 h of age. BNP levels at 24 h of age were significantly correlated with the magnitudes of the ductal shunt but not at 12 h of age. The area under the receiver operator characteristic curve of BNP levels for prediction of hsPDA at 24 h of age was 0.830. At the cutoff BNP levels of 200 and 900 pg\/ml at 24 h of age, sensitivity was 83.9 and 54.8% and specificity was 61.9 and 95.2%, respectively. <b><i>Conclusions:<\/i><\/b> BNP levels at 24 h of age can be used as a guide for early targeted treatment of hsPDA and avoid the unnecessary use of cyclooxygenase inhibitors in ELBW infants.<\/jats:p>","DOI":"10.1159\/000343034","type":"journal-article","created":{"date-parts":[[2012,11,26]],"date-time":"2012-11-26T07:59:49Z","timestamp":1353916789000},"page":"118-122","source":"Crossref","is-referenced-by-count":25,"title":["Can Early B-Type Natriuretic Peptide Assays Predict Symptomatic Patent Ductus Arteriosus in Extremely Low Birth Weight Infants?"],"prefix":"10.1159","volume":"103","author":[{"given":"Jang Hoon","family":"Lee","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeong Hee","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu Hee","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Young Jun","family":"Rhie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon Sung","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung Min","family":"Choi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.104.6.1345"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2010.02.062"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2010.05.022"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000153098"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00431-009-0983-3"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000334826"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000330411"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199807303390507"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053%2Fpcad.2002.24599"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2004-1837"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jp.7211383"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1203%2FPDR.0b013e3181799594"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2005-1387"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2005.03.040"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1038%2Fjp.2010.47"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2009.12.045"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.earlhumdev.2010.04.003"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/343034","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/343034","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:20:47Z","timestamp":1745432447000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000343034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,24]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,1]]},"published-print":{"date-parts":[[2013,2,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000343034","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,24]]}}}