{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:28:22Z","timestamp":1789039702483,"version":"build-2803163510"},"reference-count":19,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2012]]},"abstract":"<b><i>Background:<\/i><\/b> The aim of this work was to evaluate the interactions between aminoglycosides and the ethyl-acetate fraction of the fern <i>Lygodium venustum<\/i> SW (EAFLV) <b><i>Methods:<\/i><\/b> The ethyl-acetate fraction was obtained from the ethanol extract of <i>L. venustum<\/i> and was assayed via the checkerboard method associated with aminoglycosides against two bacterial strains multiresistant to antibiotics. <b><i>Results:<\/i><\/b> The antibiotic activity of all drugs, when associated with the ethyl-acetate fraction, was enhanced in an additive manner, except for the association between EAFLV and amikacin, which showed a synergistic interaction against the <i>Escherichia coli<\/i> strain. <b><i>Conclusions:<\/i><\/b> The results indicated that <i>L. venustum<\/i> can be a source of secondary metabolites to be used in association with antibiotics like aminoglycosides in antibiotic chemotherapy against resistant bacteria.<\/jats:p>","DOI":"10.1159\/000343044","type":"journal-article","created":{"date-parts":[[2012,11,16]],"date-time":"2012-11-16T08:15:37Z","timestamp":1353053737000},"page":"337-340","source":"Crossref","is-referenced-by-count":14,"title":["Phenolic Compounds and Interaction between Aminoglycosides and Natural Products of <b><i>Lygodium venustum <\/i><\/b>SW against Multiresistant Bacteria"],"prefix":"10.1159","volume":"58","author":[{"given":"M.F.B.","family":"Morais-Braga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.M.","family":"Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.K.A.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.M.M.","family":"Guedes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.C.","family":"Andrade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.R.","family":"Tintino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.E.","family":"Sobral-Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.G.M.","family":"Costa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.F.","family":"Saraiva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.D.M.","family":"Coutinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,11,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jep.2009.12.022"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jep.2007.06.001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jep.2005.02.022"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1590%2FS1516-93322006000200004"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1590%2FS0102-695X2005000200014"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1590%2FS0102-695X2010000100008"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.phymed.2008.06.008"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1159%2F000328975"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186%2F1472-6882-9-35"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3109%2F13880200902991540"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000323620"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.foodchem.2010.11.165"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1590%2FS1516-93322003000400007"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2F0378-8741%2896%2985514-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1271%2Fbbb.66.1009"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.sajb.2009.06.010"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1750-3841.2007.00387.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2621.1994.tb08154.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1750-3841.2011.02213.x"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/343044","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/343044","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/343044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:20:54Z","timestamp":1745432454000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000343044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":19,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,1,1]]},"published-print":{"date-parts":[[2013,1,23]]}},"URL":"https:\/\/doi.org\/10.1159\/000343044","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"value":"0009-3157","type":"print"},{"value":"1421-9794","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}