{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:26:11Z","timestamp":1761895571532,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T00:00:00Z","timestamp":1354060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T00:00:00Z","timestamp":1354060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Aim: To address the incidence and the prognostic role of a very early standard complete cytogenetic response (CCyR) or all Ph\u2013 metaphases (MET\u2013, when &lt;20 cells were evaluable). Methods: We revised 182 chronic phase chronic myelogenous leukemia patients treated with frontline imatinib (IM) at two institutions from June 2002 to June 2011. Results: After 3 months of treatment, 138 patients (75.8%) achieved CCyR\/MET\u2013 while 44 patients (24.2%) still presented Ph+ metaphases (MET+) (&lt;33%, 24 patients; \u226533%, 20 patients). On univariate analysis, palpable spleen enlargement (p &lt; 0.001), WBC count &gt;100.0 \u00d7 109\/l at onset (p &lt; 0.001), and male gender (p = 0.019) had a negative impact on achievement of CCyR\/MET\u2013 at 3 months. Among patients with CCyR\/MET\u2013 after 3 months, there were 15 failures (10.8%) compared to 21 (47.7%) among patients with MET+ (p &lt; 0.001). The 5-year overall survival was 97.0% in patients CCyR\/MET\u2013 at 3 months and 91.8% in patients MET+ at 3 months (p = 0.277); the 5-year progression-free survival was 88.2% in patients CCyR\/MET\u2013 at 3 months and 48.4% in patients MET+ at 3 months (p &lt; 0.001). Conclusions: The achievement of CCyR\/MET\u2013 at 3 months seems to have prognostic relevance and could be a very early and useful indicator of an excellent response to IM beyond European LeukemiaNet guidelines.<\/jats:p>","DOI":"10.1159\/000343384","type":"journal-article","created":{"date-parts":[[2012,11,28]],"date-time":"2012-11-28T11:32:30Z","timestamp":1354102350000},"page":"126-134","source":"Crossref","is-referenced-by-count":3,"title":["Complete Clearance of Ph+ Metaphases after 3 Months Is a Very Early Indicator of Good Response to Imatinib as Front-Line Treatment in Chronic Myelogenous 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