{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T03:03:23Z","timestamp":1780715003399,"version":"3.54.1"},"reference-count":17,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,11,27]],"date-time":"2012-11-27T00:00:00Z","timestamp":1353974400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,11,27]],"date-time":"2012-11-27T00:00:00Z","timestamp":1353974400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To investigate serum 5-HT level in premature ejaculation (PE) patients and evaluate its clinical value in diagnosis and treatment of PE. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; 71 patients were recruited in this study. Their serums were collected before and after sertraline treatment, while serums from 64 normal males were also collected as a control. Serum 5-HT level was detected by ELISA. SPSS 17.0 software was used to analyze the level of serum 5-HT and the ROC curve was drawn. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The average serum 5-HT level of PE patients was 61.9 ng\/ml in our study, which was significantly lower than that of the control group (120.6 ng\/ml), with statistical significance (p &lt; 0.01). After sertraline treatment, the average serum 5-HT level in PE patients was 98.9 ng\/ml, which was significantly higher than that before sertraline treatment. Sensitivity and specificity for serum 5-HT as a predictive diagnostic tool for PE were 92.2 and 93.0%, respectively, and the cutoff value of serum 5-HT was 86.4 ng\/ml. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Our study showed that serum 5-HT level may be used as a functional diagnostic tool for PE and an indicator in PE treatment.<\/jats:p>","DOI":"10.1159\/000343736","type":"journal-article","created":{"date-parts":[[2012,11,27]],"date-time":"2012-11-27T10:28:19Z","timestamp":1354012099000},"page":"214-218","source":"Crossref","is-referenced-by-count":13,"title":["Clinical Value of Serum 5-HT Level in Diagnosis and Treatment of Premature Ejaculation"],"prefix":"10.1159","volume":"90","author":[{"given":"Changhai","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunlong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baolong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,11,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-410X.2008.08165.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1743-6109.2004.04033.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1743-6109.2005.20353.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2805%2900341-1"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1743-6109.2004.10108.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1464-410X.2008.07719.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11934-010-0144-2"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2165%2F00019053-199813010-00015"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2005.05.012"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1743-6109.2006.00307.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2801%2901151-7"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ijir.3900368"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1464-410X.2003.04052.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ijir.3901023"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2006.05.055"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00005392-200212000-00004"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.psc.2011.11.002"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/343736","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/343736","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:27:34Z","timestamp":1745432854000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000343736"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,27]]},"references-count":17,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,1]]},"published-print":{"date-parts":[[2013,2,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000343736","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,27]]}}}