{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T22:40:15Z","timestamp":1777329615724,"version":"3.51.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["ORL"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; Staging for tongue carcinoma does not consider its depth of invasion. We aim to determine the prognostic significance of invasion depth in tongue cancer. &lt;b&gt;&lt;i&gt;Materials and Methods:&lt;\/i&gt;&lt;\/b&gt; Retrospective review of patients with tongue carcinoma who underwent curative surgery between 2002 and 2005; 67 patients were analyzed. Tumors were divided into 2 groups: group A = invasion depth &lt;4 mm; group B = invasion depth \u22654 mm. Recurrence and survival rates were calculated for each group and compared. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The local recurrence rate in group B was significantly higher (10 vs. 29.7%, p = 0.048). Group A patients had a superior 5-year overall survival (68.8 vs. 41.6%, p = 0.012), disease-specific survival (67.1 vs. 41.1%, p = 0.026) and local recurrence-free survival (89.5 vs. 65.4%, p = 0.035). Five-year regional recurrence, locoregional recurrence and distant recurrence-free survival rates were not significantly different between the 2 groups (p = 0.390, p = 0.173 and p = 0.207). The impact of invasion depth on survival was maintained on multivariate analysis (p = 0.031). &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Invasion depth is an important prognostic indicator in tongue cancer.<\/jats:p>","DOI":"10.1159\/000343796","type":"journal-article","created":{"date-parts":[[2012,11,2]],"date-time":"2012-11-02T13:48:58Z","timestamp":1351864138000},"page":"264-270","source":"Crossref","is-referenced-by-count":64,"title":["Prognostic Significance of Invasion Depth in Oral Tongue Squamous Cell Carcinoma"],"prefix":"10.1159","volume":"74","author":[{"given":"Winson Jianhong","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claramae Shulyn","family":"Chia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiang Khoon","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khee-Chee","family":"Soo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. Gopalakrishna","family":"Iyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,11,2]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.3322%2Fcanjclin.55.2.74"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Farchotol.1987.01860110057008"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9610%2889%2990122-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0347%28199705%2919%3A3%3C205%3A%3AAID-HED7%3E3.0.CO%3B2-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053%2Fjoms.2002.33240"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001%2Farchotol.1992.01880050029006"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2Fhed.10130"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS1368-8375%2802%2900142-2"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2Fhed.20275"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.3342%2Fceo.2008.1.3.166"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0347%28199803%2920%3A2%3C138%3A%3AAID-HED7%3E3.0.CO%3B2-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ijom.2008.07.014"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0714.2009.00797.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1186%2F1748-717X-5-43"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.26229"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1177%2F0194599810394988"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0347%28199710%2919%3A7%3C583%3A%3AAID-HED4%3E3.0.CO%3B2-3"}],"container-title":["ORL"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/343796","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/343796","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:28:09Z","timestamp":1745432889000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000343796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":17,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2013,1,1]]},"published-print":{"date-parts":[[2013,1,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000343796","archive":["Portico"],"relation":{},"ISSN":["0301-1569","1423-0275"],"issn-type":[{"value":"0301-1569","type":"print"},{"value":"1423-0275","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}