{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T17:50:17Z","timestamp":1783792217020,"version":"3.55.0"},"reference-count":32,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Endocrine complications after acute lymphoblastic leukemia (ALL) are common. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Final height, GH\/IGF-1 axis, and body mass index were analyzed after 13.7 (7.0\u201320.7) years from diagnosis in 34 boys aged &lt;12 years at diagnosis and 41 girls &lt;10 years at diagnosis. A modified German BFM-83 ALL protocol included (n = 42) or did not include (n = 33) prophylactic cranial irradiation. In 27 patients, GH after insulin tolerance test, IGF-1, cortisol, free T&lt;sub&gt;4&lt;\/sub&gt; and estradiol\/testosterone were determined. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Final height was significantly reduced (mean Z-score for height between final height and diagnosis, \u0394HAZ = \u20130.61, p = 0.0001). At that point, 3 patients were obese (4%) and 17 were overweight (22.7%). Patients aged \u22644 years at diagnosis and those irradiated had a greater loss in final height (p = 0.001 and p = 0.008, respectively). Abnormalities in GH\/IGF-1 axis were observed in 4 patients: 3 had a GH peak &lt;6 ng\/ml and 1 had a serum IGF-1 concentration &lt;25 ng\/ml. Growth deficit was significantly higher in patients with hormonal deficiency (p = 0.006). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; Treatment of ALL during childhood is associated with final height deficit. Young age at diagnosis and radiotherapy were the major risk factors. GH\/IGF-1 deficiency was found particularly in irradiated patients, even though it was detected in 1 non-irradiated patient.<\/jats:p>","DOI":"10.1159\/000343936","type":"journal-article","created":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T15:35:48Z","timestamp":1358177748000},"page":"9-16","source":"Crossref","is-referenced-by-count":10,"title":["Height Deficit and Impairment of the GH\/IGF-1 Axis in Patients Treated for Acute Lymphoblastic Leukemia during Childhood"],"prefix":"10.1159","volume":"79","author":[{"given":"Maria Ivone Oliveira Pinto","family":"Vilela","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marina de Oliveira","family":"Serravite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nat\u00e1lia Bragan\u00e7a","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patr\u00edcia Carneiro","family":"de Brito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f4nio","family":"Ribeiro-Oliveira Jr.","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Borato","family":"Viana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,1,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.12.4441"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.hoc.2008.01.011"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0268-960X%2802%2900042-5"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2888%2991246-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2003.03.068"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fpbc.20901"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1994.tb13018.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2805%2981537-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2006.11.036"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fpbc.22781"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2008-3688"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fpbc.21396"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.1.01829"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.1976.tb03563.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.71.4.304"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.45.244.755"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-911X%28199806%2930%3A6%3C351%3A%3AAID-MPO9%3E3.0.CO%3B2-D"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1530%2FEJE-07-0631"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2009-0602"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002%2Fpbc.20334"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.1995.tb13862.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2805%2980487-1"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004310050599"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1002%2Fpbc.20485"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199306000-00008"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2FS0031-3955%2805%2970487-9"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1007%2Fs004310050918"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-2599"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1038%2Fncpendmet1051"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1002%2Fpbc.20020"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.22120"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2879%2980137-7"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/343936","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/343936","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:29:55Z","timestamp":1745432995000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000343936"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":32,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,2,1]]},"published-print":{"date-parts":[[2013,2,6]]}},"URL":"https:\/\/doi.org\/10.1159\/000343936","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"value":"1663-2818","type":"print"},{"value":"1663-2826","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}