{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T06:16:53Z","timestamp":1790662613822,"version":"4.1.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background\/Aims:&lt;\/i&gt;&lt;\/b&gt; JTT-751 (ferric citrate hydrate) is a novel oral, iron-based phosphate binder being developed for the treatment of hyperphosphatemia among chronic kidney disease patients who are on dialysis. This study investigated the dose-response and safety of JTT-751 among Japanese hemodialysis patients. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; This was a multicenter, randomized, placebo-controlled, double-blind, parallel-group, comparative study. A total of 192 subjects with serum phosphorus (P) levels between 6.1 and 10.0 mg\/dl were randomized to JTT-751 (1.5, 3 or 6 g\/day) or to placebo treatment for 28 days. Changes in serum P level from baseline were examined. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; In the full analysis set, the mean change in serum P level at week 4 was 0.04, \u20131.28, \u20132.16 and \u20134.10 mg\/dl in the placebo, 1.5-grams, 3-grams and 6-grams\/day groups, respectively, demonstrating a dose-response relationship up to 6 g\/day. Overall, a reduction in serum P levels to \u22645.5 mg\/dl was achieved in 2.5, 16.7, 50.0 and 92.6% of subjects, in the placebo, 1.5-grams, 3-grams and 6-grams\/day groups, respectively. The most common adverse events (AEs) were gastrointestinal disorders. Most AEs were mild. In 25 patients, treatment was discontinued due to increased transferrin saturation \u226550%; however, this was not considered to be a safety issue. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; When hemodialysis subjects received JTT-751 at doses between 1.5 and 6 g\/day for 28 days, serum P levels were significantly reduced in a dose-dependent manner (p &lt; 0.001). JTT-751 was found to be efficacious and safe, with the majority of subjects in the 6-grams\/day group achieving a serum P level of \u22645.5 mg\/dl.<\/jats:p>","DOI":"10.1159\/000344008","type":"journal-article","created":{"date-parts":[[2012,11,8]],"date-time":"2012-11-08T11:30:02Z","timestamp":1352374202000},"page":"478-487","source":"Crossref","is-referenced-by-count":60,"title":["Effect of Oral JTT-751 (Ferric Citrate) on Hyperphosphatemia in Hemodialysis Patients: Results of a Randomized, Double-Blind, Placebo-Controlled Trial"],"prefix":"10.1159","volume":"36","author":[{"given":"Keitaro","family":"Yokoyama","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Hirakata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Akiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Sawada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuji","family":"Kumagai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,11,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.2008.130"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2896%2990363-7"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2803%2900372-X"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.4009%2Fjsdt.39.1435"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ki.5000414"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.2215%2FCJN.05130610"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0272-6386%2897%2990352-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1973.39"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00041552-200307000-00005"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093%2Foxfordjournals.ndt.a027394"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F14.4.863"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F17.2.265"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.2010.23"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1797.2011.01509.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1744-9987.2007.00541.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.5414%2FCNP70404"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.krcp.2012.04.414"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.2010.108"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.055Suppl.69061.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.2010.382"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/344008","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/344008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:30:36Z","timestamp":1745433036000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000344008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":20,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2012,11,1]]},"published-print":{"date-parts":[[2012,11,26]]}},"URL":"https:\/\/doi.org\/10.1159\/000344008","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}