{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T17:24:49Z","timestamp":1783445089722,"version":"3.54.6"},"reference-count":23,"publisher":"Bioscientifica","issue":"4","license":[{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":4827,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2013,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Riedel\u2019s thyroiditis is characterised by chronic inflammatory invasive fibrosclerosis of the thyroid gland, surrounding structures, and extrathyroidal fibrosis. We present a case of Riedel\u2019s thyroiditis associated with nodular fibrosis of the lungs and liver. Case: A 40-year-old woman presented with a 3-month history of neck swelling, difficulty swallowing and breathlessness on exertion. Core biopsy of the goitre revealed dense fibrous tissue with mixed chronic inflammatory cells. A staging computed tomography scan revealed a large thyroid mass encasing the oesophagus and compressing the trachea, multiple bilateral pulmonary nodules with no evidence of lymphadenopathy, and multiple suspicious nodular lesions in the liver. A thorascopic biopsy of a lung lesion in its entirety revealed a hyalinising lung lesion with no evidence of malignancy. Following the introduction of levothyroxine replacement, symptomatic improvement occurred in parallel with improvements in imaging. Conclusion: To our knowledge, this is the first description of Riedel\u2019s thyroiditis presenting with nodular extrathyroidal fibrosis, and which showed resolution following institution of levothyroxine.<\/jats:p>","DOI":"10.1159\/000345032","type":"journal-article","created":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T02:49:09Z","timestamp":1354157349000},"page":"259-263","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-17","source":"Crossref","is-referenced-by-count":0,"title":["Atypical Presentation of Riedel\u2019s Thyroiditis: Multifocal Nodular Fibrosis and Resolution with Levothyroxine"],"prefix":"10.1530","volume":"1","author":[{"given":"Sampath Satish","family":"Kumar","sequence":"first","affiliation":[{"name":"1Departments of Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Fraser","sequence":"additional","affiliation":[{"name":"2Departments of Endocrine Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Scarsbrook","sequence":"additional","affiliation":[{"name":"3Departments of Radiology, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"MacLennan","sequence":"additional","affiliation":[{"name":"4Leeds Institute of Molecular Medicine, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Lansdown","sequence":"additional","affiliation":[{"name":"2Departments of Endocrine Surgery, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert D.","family":"Murray","sequence":"additional","affiliation":[{"name":"1Departments of Endocrinology, Leeds Teaching Hospitals NHS Trust, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2012,11,29]]},"reference":[{"key":"2026070712422058800_ref1","unstructured":"Riedel BM: Die chronische, zur Bildung eisenharter Tumoren f\u00fchrende Entz\u00fcndung der Schilddr\u00fcse. 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