{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T20:13:53Z","timestamp":1785442433236,"version":"3.56.0"},"reference-count":27,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T00:00:00Z","timestamp":1354147200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T00:00:00Z","timestamp":1354147200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroimmunomodulation"],"published-print":{"date-parts":[[2013]]},"abstract":"Aging in female rats is associated with cessation of reproductive cycles, development of mammary cancer, and increased incidence of autoimmune diseases. Previously, we demonstrated an age-related decline in sympathetic noradrenergic (NA) innervation in the spleen and lymph nodes of female F344 rats accompanied by significantly reduced natural killer cell activity, interleukin (IL)-2 and interferon (IFN)-\u03b3 production, and T- and B-cell proliferation, suggesting possible links between sympathetic activity and immunosenescence. <b><i>Objectives:<\/i><\/b> The aim of this study is to investigate the effects of <smlcap>l<\/smlcap>-(\u2013)-deprenyl, a monoamine oxidase-B inhibitor, on the sympathetic nervous system and cell-mediated immune responses in old female rats. <b><i>Methods:<\/i><\/b> Low doses of <smlcap>l<\/smlcap>-deprenyl (0.25 or 1.0 mg\/kg body weight, BW) were administered intraperitoneally to 19- to 21-month-old female F344 rats for 8 weeks. To assess the stereoselectivity of the effects of deprenyl on splenic sympathetic activity and immune responses, the <smlcap>d<\/smlcap>-enantiomer (<smlcap>d<\/smlcap>-(+)-deprenyl; 1.0 mg\/kg BW) was also included in the studies. Norepinephrine (NE) concentration and content, and mitogen-induced T-cell proliferation and cytokine production were assessed in the splenocytes after deprenyl treatment. <b><i>Results:<\/i><\/b> Treatment with <smlcap>l<\/smlcap>-deprenyl reversed the age-related decrease in NE concentration and content and IFN-\u03b3 production, and increased IL-2 production in the spleen while <smlcap>d<\/smlcap>-deprenyl did not affect the age-associated reduction in splenic NE levels or cytokine production. <b><i>Conclusions:<\/i><\/b> These findings demonstrate that <smlcap>l<\/smlcap>-deprenyl exerts neurorestorative and immunostimulatory effects on the sympathetic nervous system and cell-mediated immune responses during aging and provides evidence for a causal relationship between some aspects of immunosenescence and the age-related decline in sympathetic nerves in the spleens of female F344 rats.<\/jats:p>","DOI":"10.1159\/000345043","type":"journal-article","created":{"date-parts":[[2012,11,29]],"date-time":"2012-11-29T07:49:01Z","timestamp":1354175341000},"page":"72-78","source":"Crossref","is-referenced-by-count":11,"title":["<smlcap>l<\/smlcap>-Deprenyl Reverses Age-Associated Decline in Splenic Norepinephrine, Interleukin-2 and Interferon-\u03b3 Production in Old Female F344 Rats"],"prefix":"10.1159","volume":"20","author":[{"given":"Srinivasan","family":"ThyagaRajan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley S.","family":"Madden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary W.","family":"Boehm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne Y.","family":"Stevens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David L.","family":"Felten","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise L.","family":"Bellinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,11,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0047-6374%2801%2900390-6"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cellimm.2007.09.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0197-4580%2887%2990026-1"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-4886%2892%2990009-F"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fajhb.22243"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3945%2Fajcn.2009.26736J"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.mam.2011.11.002"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.coi.2009.06.002"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-5728%2897%2900169-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-5728%2898%2900039-3"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-5728%2800%2900305-2"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0192-0561%2800%2900016-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.2174%2F1389450110607011513"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11064-010-0238-8"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jneuroim.2010.11.012"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2F0047-6374%2888%2990024-3"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1590%2FS0100-879X2006005000140"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1159%2F000214842"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2F978-3-7091-6499-0_33"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2F0165-5728%2894%2990183-X"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.arr.2009.11.003"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.it.2009.03.013"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2FS0047-6374%2801%2900392-X"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-2999%2896%2900593-6"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00213-005-0200-7"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2F0024-3205%2891%2990570-2"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2FS1567-5769%2802%2900047-4"}],"container-title":["Neuroimmunomodulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345043","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:31:05Z","timestamp":1745433065000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000345043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,29]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,1,1]]},"published-print":{"date-parts":[[2013,1,31]]}},"URL":"https:\/\/doi.org\/10.1159\/000345043","archive":["Portico"],"relation":{},"ISSN":["1021-7401","1423-0216"],"issn-type":[{"value":"1021-7401","type":"print"},{"value":"1423-0216","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,29]]}}}