{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T20:25:09Z","timestamp":1780518309961,"version":"3.54.1"},"reference-count":24,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To investigate what changes are endoscopically evident after glycosaminoglycans (GAGs) therapy by hyaluronic acid (HA) and chondroitin sulphate (CS) (Ialuril\u00ae) in female patients affected by bladder pain syndrome(BPS)\/ interstitial cystitis (IC) or recurrent urinary tract infections (rUTIs). &lt;b&gt;&lt;i&gt;Patients and Methods:&lt;\/i&gt;&lt;\/b&gt; 21 female patients over 18 years affected by rUTIs or BPS\/IC received intravesical instillation of HA and CS (4 weekly instillations followed by 2 instillations every 2 weeks and 2 instillation monthly). Post-treatment evaluation included cystoscopy and patient assessment of improvement in symptoms and satisfaction on a visual analogue scale (VAS) from 0 to 10. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; The post-treatment endoscopy showed a positive effect on bladder mucosa morphology. In 2 cases, treatment did not change endoscopic findings and clinical symptoms. In the other patients, when macroscopic features of the bladder mucosa normalized, the clinical picture improved. &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; GAGs therapy by HA and CS (Ialuril) improves the morphology of bladder mucosa in patients with rUTI or BPS\/IC.<\/jats:p>","DOI":"10.1159\/000345047","type":"journal-article","created":{"date-parts":[[2013,3,13]],"date-time":"2013-03-13T07:42:09Z","timestamp":1363160529000},"page":"81-88","source":"Crossref","is-referenced-by-count":25,"title":["Morphological Changes of Bladder Mucosa in Patients Who Underwent Instillation with Combined Sodium Hyaluronic Acid-Chondroitin Sulphate (Ialuril\u00ae)"],"prefix":"10.1159","volume":"91","author":[{"given":"E.","family":"Costantini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Lazzeri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Pistolesi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Del Zingaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Frumenzio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Boni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Pietropaolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Fragal\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Porena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,3,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159\/000339251"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eursup.2011.06.001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2011.03.039"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159\/000317441"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2010.12.039"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.09.019"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159\/000090876"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007\/BF00182049"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2004.04850.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2006.11.025"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-012-1794-z"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00427-08"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0854.2004.00251.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.69.7.4572-4579.2001"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000338098"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097\/01.mou.0000232048.81965.16"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2007.03.020"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/BF01907075"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-010-1294-y"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/S1569-9056(03)00035-6"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410X.2008.08028.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2174\/157488708784223817"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-008-0572-4"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1007\/s00192-012-1742-y"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345047","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345047","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:31:09Z","timestamp":1745433069000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000345047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":24,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,7,1]]},"published-print":{"date-parts":[[2013,7,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000345047","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}