{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,22]],"date-time":"2025-07-22T10:57:56Z","timestamp":1753181876629,"version":"3.40.4"},"reference-count":27,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Purpose:&lt;\/i&gt;&lt;\/b&gt; To evaluate the diagnostic value of microperimetry (MP), blue-on-yellow perimetry (B\/YP), confocal scanning laser ophthalmoscopy (Heidelberg Retina Tomograph, HRT, III) and optical coherence tomography (OCT) in discriminating eyes with early glaucoma from healthy subjects. &lt;b&gt;&lt;i&gt;Material and Methods:&lt;\/i&gt;&lt;\/b&gt; Prospective examination of 22 eyes of subjects with early primary open-angle glaucoma and 24 eyes of healthy control subjects. After a complete ophthalmological examination, B\/YP, MP, OCT and HRT III were determined. Morphological and functional parameters were analysed. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Mean sensitivity threshold values obtained with B\/YP and MP did not show significant differences between glaucoma patients and the control group (p = 0.321 and p = 0.281). Retinal nerve fibre layer (RNFL) thickness was significantly decreased in patients with glaucoma with both HRT III and OCT (p = 0.018 and p &lt; 0.001). &lt;b&gt;&lt;i&gt;Conclusions:&lt;\/i&gt;&lt;\/b&gt; While B\/YP and MP had no ability to discriminate between subjects with early glaucoma and healthy subjects, RNFL thickness measured with HRT III and OCT showed a significant difference. In early primary open-angle glaucoma, morphological changes like RNFL thickness seem to occur prior to functional defects in the visual field.<\/jats:p>","DOI":"10.1159\/000345074","type":"journal-article","created":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T07:53:03Z","timestamp":1358149983000},"page":"192-198","source":"Crossref","is-referenced-by-count":14,"title":["Comparison of Functional and Morphological Diagnostics in Glaucoma Patients and Healthy Subjects"],"prefix":"10.1159","volume":"49","author":[{"given":"M.K.J.","family":"Klamann","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Gr\u00fcnert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.-K.B.","family":"Maier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Gonnermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Joussen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.K.","family":"Huber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,1,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.1991.01080010079037"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.1982.01030030137016"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.06-0688"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.preteyeres.2004.10.002"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.05-1584"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.06-1086"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02028639"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2800%2900341-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2802%2901296-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.1995.01100050054031"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2802%2901564-6"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-6420%2801%2900676-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9394%2803%2900084-9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1167%2Fiovs.05-1239"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajo.2007.06.021"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.1993.01090060119035"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0420.80.s236.9.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.1993.01090050085035"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.118.9.1231"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1001%2Farchopht.1993.01090050079034"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ophtha.2004.04.017"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1442-9071.2009.02031.x"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0420.80.s236.9.x"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajo.2004.08.036"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajo.2004.08.069"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1097%2FIJG.0b013e31802dfc1d"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajo.2007.07.010"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345074","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345074","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345074","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:31:23Z","timestamp":1745433083000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000345074"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":27,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,5,1]]},"published-print":{"date-parts":[[2013,5,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000345074","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"type":"print","value":"0030-3747"},{"type":"electronic","value":"1423-0259"}],"subject":[],"published":{"date-parts":[[2013]]}}}