{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T12:25:44Z","timestamp":1769343944031,"version":"3.49.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Photodynamic therapy (PDT) represents an optimal treatment for basal cell carcinoma (BCC). Reflectance confocal microscopy (RCM) is a noninvasive imaging tool that has been applied in skin oncology and for BCC diagnosis. Moreover, RCM is a useful tool to determine noninvasive treatment efficacy of nonmelanoma skin cancer. &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; We aimed to investigate the role of RCM in assessing the efficacy of PDT in the treatment of BCC and to evaluate the skin changes following the PDT. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Ten patients with 12 BCCs were treated with PDT. Dermoscopy and RCM imaging were performed at baseline as well as 7 days (T1), 30 days and 18 months after PDT. Cytological examination was taken at baseline and in case of BCC persistence. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; At T1, RCM showed the presence of several dendritic-shaped cells within the epidermis, corresponding to activated Langerhans cells. After 1 month, RCM showed the persistence of 2 BCCs, which escaped the clinical and dermoscopic diagnosis. At the long-term follow-up, none of the tumors revealed signs of persistence or recurrence. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; RCM is a valuable noninvasive tool for the diagnosis and treatment monitoring of BCC using PDT.<\/jats:p>","DOI":"10.1159\/000345106","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T14:33:50Z","timestamp":1355409230000},"page":"264-270","source":"Crossref","is-referenced-by-count":41,"title":["Confocal Microscopy Insights into the Treatment and Cellular Immune Response of Basal Cell Carcinoma to Photodynamic Therapy"],"prefix":"10.1159","volume":"225","author":[{"given":"Caterina","family":"Longo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alice","family":"Casari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Patrizia","family":"Pepe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elvira","family":"Moscarella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iris","family":"Zalaudek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Argenziano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Pellacani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,12,13]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0781.2010.00507.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.pdpdt.2009.12.004"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2006.06.006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.2009.03430.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2008.08882.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2012.11051.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1524-4725.2005.31052"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1747.1999.00690.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2004.06.028"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.144.12.1597"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2010.10.035"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2009.05.035"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1067%2Fmjd.2002.124690"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2005.11.1096"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2009.02.036"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0560.2010.01632.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.143.7.883"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.2010.03871.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jdermsci.2008.08.005"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-0960.2011.00769.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2012.10823.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2005.08.026"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.2310%2F6620.2006.05052"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1159%2F000254893"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159%2F000339335"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345106","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345106","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:31:58Z","timestamp":1745433118000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000345106"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":25,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,1,1]]},"published-print":{"date-parts":[[2013,1,22]]}},"URL":"https:\/\/doi.org\/10.1159\/000345106","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}