{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T01:28:28Z","timestamp":1769045308381,"version":"3.49.0"},"reference-count":25,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T00:00:00Z","timestamp":1356048000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T00:00:00Z","timestamp":1356048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Addict Res"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background\/Aims:<\/i><\/b> Some patients on opioid maintenance treatment (OMT) leave treatment temporarily or permanently. This study investigated whether patients interrupting their OMT differed from non-interrupters in sociodemographic and drug-use characteristics and examined acute\/sub-acute somatic morbidity among the interrupters, prior to, during, and after OMT. <b><i>Methods:<\/i><\/b> Cohort design. <b><i>Observation Period:<\/i><\/b> 5 years prior to, up to first 5 years during, and up to 5 years after interruption of OMT. <b><i>Participants:<\/i><\/b> The sample (n = 200) comprised 51 OMT interrupters and 149 non-interrupters. Data on patient characteristics were obtained from interviews and OMT register information. Data on somatic morbidity were gathered from hospital records. <b><i>Measurements:<\/i><\/b> Key patient characteristics among OMT interrupters and non-interrupters. Incidence rates of acute and sub-acute somatic disease incidents leading to hospital treatment (drug-related\/non-drug-related\/injuries) prior to\/during\/after OMT. <b><i>Results:<\/i><\/b> Interrupters and non-interrupters did not differ in sociodemographic characteristics, while longer duration of amphetamine and benzodiazepine dependence predicted OMT interruption. Interrupters scored significantly higher on drug-taking and overdose during OMT but still had a significant 41% reduction in drug-related treatment, episodes. After interruption of treatment, such episodes increased markedly and were 3.6 times more frequent during the first post-OMT year compared to the pre-OMT period (p < 0.001). This increase was highest during the first months after OMT interruption. 2\u20135 years after interruption there was no significant increase. <b><i>Conclusions:<\/i><\/b> Increased somatic morbidity was found among OMT interrupters during the first year after OMT, and especially during the immediate post-treatment period.<\/jats:p>","DOI":"10.1159\/000345229","type":"journal-article","created":{"date-parts":[[2012,12,21]],"date-time":"2012-12-21T13:57:18Z","timestamp":1356098238000},"page":"194-201","source":"Crossref","is-referenced-by-count":9,"title":["Increased Somatic Morbidity in the First Year after Leaving Opioid Maintenance Treatment: Results from a Norwegian Cohort Study"],"prefix":"10.1159","volume":"19","author":[{"given":"I.","family":"Skeie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Brekke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Clausen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gossop","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Lindbaek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Reinertsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Thoresen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Waal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2012,12,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.drugalcdep.2009.03.020"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1360-0443.2005.01089.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1360-0443.2009.02570.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0447.1990.tb03057.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.c3172"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1360-0443.2006.01714.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3109%2F10826089609045806"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1360-0443.2004.00752.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080%2F08039480701415251"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080%2F09595230601036986"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0306-4603%2800%2900174-X"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.drugalcdep.2008.01.015"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1360-0443.2010.02999.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.3109%2F10826089809059353"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.drugalcdep.2007.11.003"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmj.c5475"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.drugalcdep.2009.05.021"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.3109%2F08039488.2010.503904"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1136%2Fbmjopen-2011-000130"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159%2F000097935"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2458-8-43"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1017%2FS0950268810000324"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1159%2F000321465"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136%2Febm1184"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1159%2F000336849"}],"container-title":["European Addiction Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345229","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345229","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:33:19Z","timestamp":1745433199000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000345229"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,21]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,6,1]]},"published-print":{"date-parts":[[2013,6,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000345229","archive":["Portico"],"relation":{},"ISSN":["1022-6877","1421-9891"],"issn-type":[{"value":"1022-6877","type":"print"},{"value":"1421-9891","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,21]]}}}