{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:33:18Z","timestamp":1791113598581,"version":"4.1.0"},"reference-count":82,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:00:00Z","timestamp":1353456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T00:00:00Z","timestamp":1353456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>Aldosterone exerts direct effects on the vascular system by inducing oxidative stress, inflammation, hypertrophic remodeling, fibrosis, and endothelial dysfunction. Aldosterone exerts its effects through genomic and nongenomic pathways in a mineralocorticoid receptor (MR)-dependent or independent manner. Other aldosterone receptors such as GPR30 have been identified. A tight relation exists between the aldosterone and angiotensin II pathways, as well as with the endothelin-1 system. There is a correlation between plasma levels of aldosterone and cardiovascular risk. Recently, an increasing body of evidence has underlined the importance of aldosterone in cardiovascular complications associated with the metabolic syndrome, such as arterial remodeling and endothelial dysfunction. Blockade of MR is an increasingly used evidence-based therapy for many forms of cardiovascular disease, including hypertension, heart failure, chronic kidney disease, and diabetes mellitus.<\/jats:p>","DOI":"10.1159\/000345243","type":"journal-article","created":{"date-parts":[[2012,11,21]],"date-time":"2012-11-21T11:53:38Z","timestamp":1353498818000},"page":"89-99","source":"Crossref","is-referenced-by-count":156,"title":["Vascular Actions of Aldosterone"],"prefix":"10.1159","volume":"50","author":[{"given":"Marie","family":"Briet","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ernesto L.","family":"Schiffrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,11,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fnrneph.2010.30"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.123.3195.503"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.37.6.1444"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0895-7061%2801%2902291-9"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161%2F01.ATV.17.6.1152"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000034738.79310.06"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000131860.80444.AB"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000176588.51027.35"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1291%2Fhypres.31.1407"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000039328.33137.6C"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0895-7061%2897%2900301-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2F01.hjh.0000170378.08214.13"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfn118"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1291%2Fhypres.28.925"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.2002-220120"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1096%2Ffj.05-4642fje"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000154365.30593.d3"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1093%2Fcvr%2Fcvr131"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.2007-0864"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161%2FHYPERTENSIONAHA.111.181123"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCRESAHA.108.174235"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9440%2810%2964454-9"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000129307.26791.8E"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000171479.36880.17"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.101.6.594"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000142858.44680.27"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1152%2Fajpheart.00552.2010"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm1545"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1161%2FHYPERTENSIONAHA.110.153619"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1006%2Fcbir.1997.0220"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00239-003-0635-6"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1748-1716.2006.01574.x"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1097%2FHJH.0b013e328013f492"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0707791104"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1093%2Feurheartj%2Fehq254"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2011-1135"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1139%2Fy85-250"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.25.2.170"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.2004-0081"},{"key":"ref40","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.104.521625"},{"key":"ref41","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000140771.21243.ed"},{"key":"ref42","doi-asserted-by":"publisher","DOI":"10.1161%2F01.RES.0000180753.63183.95"},{"key":"ref43","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cardiores.2007.07.008"},{"key":"ref44","doi-asserted-by":"publisher","DOI":"10.1161%2FATVBAHA.108.168021"},{"key":"ref45","doi-asserted-by":"publisher","DOI":"10.1093%2Fcvr%2Fcvs016"},{"key":"ref46","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCRESAHA.109.196576"},{"key":"ref47","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.21.3.294"},{"key":"ref48","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.25.4.769"},{"key":"ref49","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000144462.08345.B9"},{"key":"ref50","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1476-5381.1995.tb16626.x"},{"key":"ref51","doi-asserted-by":"publisher","DOI":"10.1016%2FS0895-7061%2897%2900405-6"},{"key":"ref52","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000078357.92682.EC"},{"key":"ref53","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M109.030718"},{"key":"ref54","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.83.10.3517"},{"key":"ref55","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.84.10.3528"},{"key":"ref56","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000083298.23119.16"},{"key":"ref57","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjcard.2004.09.047"},{"key":"ref58","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000205224.58715.cc"},{"key":"ref59","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000093188.53554.44"},{"key":"ref60","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.2004-1130"},{"key":"ref61","doi-asserted-by":"publisher","DOI":"10.1093%2Fcvr%2Fcvn064"},{"key":"ref62","doi-asserted-by":"publisher","DOI":"10.1161%2FHYPERTENSIONAHA.110.161653"},{"key":"ref63","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.25.1.117"},{"key":"ref64","doi-asserted-by":"publisher","DOI":"10.1161%2F01.RES.76.6.973"},{"key":"ref65","doi-asserted-by":"publisher","DOI":"10.1152%2Fajpcell.00407.2006"},{"key":"ref66","doi-asserted-by":"publisher","DOI":"10.1161%2F01.HYP.0000172622.51973.f5"},{"key":"ref67","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.107.708537"},{"key":"ref68","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2008-0251"},{"key":"ref69","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2007-1088"},{"key":"ref70","doi-asserted-by":"publisher","DOI":"10.1016%2F0024-3205%2892%2990062-T"},{"key":"ref71","doi-asserted-by":"publisher","DOI":"10.1096%2Ffj.07-9412com"},{"key":"ref72","doi-asserted-by":"publisher","DOI":"10.1081%2FERC-120016804"},{"key":"ref73","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.2336140100"},{"key":"ref74","doi-asserted-by":"publisher","DOI":"10.1161%2FHYPERTENSIONAHA.111.190223"},{"key":"ref75","doi-asserted-by":"publisher","DOI":"10.1161%2FHYPERTENSIONAHA.110.168872"},{"key":"ref76","doi-asserted-by":"publisher","DOI":"10.1161%2FATVBAHA.111.240697"},{"key":"ref77","doi-asserted-by":"publisher","DOI":"10.1161%2FHYPERTENSIONAHA.107.093955"},{"key":"ref78","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa030207"},{"key":"ref79","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199909023411001"},{"key":"ref80","doi-asserted-by":"publisher","DOI":"10.1161%2FHYPERTENSIONAHA.107.103267"},{"key":"ref81","doi-asserted-by":"publisher","DOI":"10.1161%2FHYPERTENSIONAHA.110.157271"},{"key":"ref82","doi-asserted-by":"publisher","DOI":"10.1161%2FCIRCULATIONAHA.111.029892"}],"container-title":["Journal of Vascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:33:28Z","timestamp":1745418808000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000345243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11,21]]},"references-count":82,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,2,1]]},"published-print":{"date-parts":[[2013,2,14]]}},"URL":"https:\/\/doi.org\/10.1159\/000345243","archive":["Portico"],"relation":{},"ISSN":["1018-1172","1423-0135"],"issn-type":[{"value":"1018-1172","type":"print"},{"value":"1423-0135","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,11,21]]}}}