{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:44:19Z","timestamp":1791564259256,"version":"4.3.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2012,12,22]],"date-time":"2012-12-22T00:00:00Z","timestamp":1356134400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,12,22]],"date-time":"2012-12-22T00:00:00Z","timestamp":1356134400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Severe neonatal hyperbilirubinemia, with consequent encephalopathy, remains a common cause of morbidity and death in many regions of the world. Poor access to clinical laboratory resources and screening programs to measure plasma bilirubin levels is a major contributor to delayed treatment in developing countries, and the cost of existing point-of-care screening instruments precludes their dissemination. &lt;b&gt;&lt;i&gt;Objectives:&lt;\/i&gt;&lt;\/b&gt; We are evaluating the accuracy of a low-cost, minimally invasive point-of-care system (Bilistick) requiring a 25-\u00b5l blood sample that could be used in low-resource environments to evaluate patients with neonatal jaundice. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; We compared plasma bilirubin levels in divided blood samples by clinical laboratories and by Bilistick at two medical centers serving term and near-term newborns from ethnically different populations. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; 118 neonates with bilirubin levels ranging from 24.8 to 501.0 \u00b5mol\/l were analyzed. The mean bilirubin concentration (\u00b1SD) was 215.6 \u00b1 85.5 \u00b5mol\/l for Bilistick and 226.1 \u00b1 86.4 \u00b5mol\/l by laboratory determination. Pearson\u2019s correlation coefficient between all paired results was 0.961, and the Bland-Altman analysis showed a mean difference of 10.3 \u00b5mol\/l with a 95% interval of agreement of \u201338.0 to 58.7 \u00b5mol\/l. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; Bilistick is a minimally invasive method for measuring total bilirubin concentration over a wide range of values and should provide an affordable and accurate system for pre-discharge and follow-up screening of jaundiced infants, particularly in low-resource environments.<\/jats:p>","DOI":"10.1159\/000345425","type":"journal-article","created":{"date-parts":[[2012,12,27]],"date-time":"2012-12-27T03:00:48Z","timestamp":1356577248000},"page":"177-181","source":"Crossref","is-referenced-by-count":65,"title":["Bilistick: A Low-Cost Point-of-Care System to Measure Total Plasma Bilirubin"],"prefix":"10.1159","volume":"103","author":[{"given":"C.D.","family":"Coda Zabetta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.F.","family":"Iskander","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Greco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bellarosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Demarini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Tiribelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.P.","family":"Wennberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2012,12,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.semperi.2004.09.002"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2362.2003.01261.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1385%2FNMM%3A8%3A4%3A513"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000321990"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-3476%2895%2970510-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Ftropej%2Ffmq045"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1515%2FJPM.1999.037"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.2005-0590"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.semperi.2011.02.014"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000330055"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1651-2227.2012.02797.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000107351"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.110.1.61"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jp.7211333"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2431-9-70"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-2431-12-70"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clinbiochem.2012.03.014"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1038%2Fjp.2011.5"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1515%2Fcclm.2010.279"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.jp.7211436"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345425","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345425","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:35:40Z","timestamp":1745418940000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000345425"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,12,22]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,3,1]]},"published-print":{"date-parts":[[2013,3,20]]}},"URL":"https:\/\/doi.org\/10.1159\/000345425","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,12,22]]}}}