{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:19:42Z","timestamp":1767831582938,"version":"3.49.0"},"reference-count":14,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmic Res"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Aims:<\/i><\/b> The aim of the present study was to evaluate the cicatricial repair of a corneal artificial perforation in rats with 10-0 nylon suture, N-butyl-2-cyanoacrylate (NBCA) adhesive, or NBCA + methacryloxysulfolane (NBCA-MS) adhesive through microscopic and histological assays. <b><i>Methods:<\/i><\/b> Twenty Wistar rats were randomly divided into 4 groups each containing 5 rats: (1) control group (corneal trauma without suturing and tissue adhesives), (2) suture group, (3) NBCA group and (4) NBCA-MS group. A central full-thickness 2-mm laceration was performed in the left eyes of the studied rats in all 4 groups. The presence of corneal edema, corneal neovascularization and tissue adhesive\/suture were evaluated. On the 21st day, the rats were sacrificed and histological examination was performed to determine irregularity of corneal layers, superficial epithelization, polymorphonuclear leucocytes and neovascularization. <b><i>Results:<\/i><\/b> Tissue adhesives were as effective as suturing in closing full-thickness corneal wounds and no difference in postoperative healing was observed clinically. As for the histological results, suture-treated eyes had persistent corneal irregularity that can limit visual acuity and may also lead to astigmatism. <b><i>Conclusions:<\/i><\/b> The use of tissue adhesives constitutes a viable alternative clinical procedure to conventional sutures. Possible influences on astigmatism are hypothetical, as no objective measure of astigmatism was performed in the test animals.<\/jats:p>","DOI":"10.1159\/000345451","type":"journal-article","created":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T07:53:03Z","timestamp":1358149983000},"page":"199-204","source":"Crossref","is-referenced-by-count":6,"title":["Comparison of Sutures and Cyanoacrylate Tissue Adhesives for Wound Repair in a Rat Model of Corneal Laceration"],"prefix":"10.1159","volume":"49","author":[{"given":"Fadime","family":"Nuhoglu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ugur E.","family":"Altiparmak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dicle O.","family":"Hazirolan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Remzi","family":"Kasim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunay","family":"Duman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,1,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200408000-00006"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1997.03540430071037"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/jab.770010203"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.1997.tb00103.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/0014-4835(84)90079-4"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1968.00980050707004"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1177\/155335060501200304"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.1997.7230133.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000164780.25914.0a"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2004.08.028"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2003.032854"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1080\/02713680500477354"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000183493.00884.8f"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0b013e328012166e"}],"container-title":["Ophthalmic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345451","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345451","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345451","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:36:02Z","timestamp":1745433362000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000345451"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":14,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,5,1]]},"published-print":{"date-parts":[[2013,5,16]]}},"URL":"https:\/\/doi.org\/10.1159\/000345451","archive":["Portico"],"relation":{},"ISSN":["0030-3747","1423-0259"],"issn-type":[{"value":"0030-3747","type":"print"},{"value":"1423-0259","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}