{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:34:51Z","timestamp":1745469291692,"version":"3.40.4"},"reference-count":32,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Transfus Med Hemother"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Xenotropic murine leukemia virus-related virus (XMRV) is a retrovirus that has recently been related to prostate cancers and chronic fatigue syndrome. Since other human-pathogenic retroviruses, such as HIV, human T-lymphotropic virus type I (HTLV-I) and \u2013II, are known blood-transmitted pathogens, XMRV might present another hazard associated with products derived from in vitro cultures of human or animal origin, or blood component-based therapeutics. Here, we investigated whether XMRV was transmitted to individuals with hemophilia and frequent exposure to plasma-derived or recombinant clotting factors. &lt;b&gt;&lt;i&gt;Methods: &lt;\/i&gt;&lt;\/b&gt;We used highly sensitive real-time PCR to test plasma samples from 127 consecutive individuals with hemophilia who consulted our hemophilia center either for treatment or for a standard check-up. &lt;b&gt;&lt;i&gt;Results: &lt;\/i&gt;&lt;\/b&gt;From the 127 hemophiliacs, 80 had prior contact to persons with either hepatitis B (n = 30), hepatitis C (n = 74) and\/or HIV (n = 21), and 30 were currently being treated with plasma-derived and 97 with recombinant factor concentrates. None of the individuals tested positive for XMRV. &lt;b&gt;&lt;i&gt;Conclusions: &lt;\/i&gt;&lt;\/b&gt;Independent of the ongoing discussion on whether the positive XMRV testing in initial reports was a result of reagent, sample, or tissue contamination, and whether XMRV is a real threat or a testing artifact, our data suggest that XMRV might not play an important role for hemophiliacs.<\/jats:p>","DOI":"10.1159\/000345661","type":"journal-article","created":{"date-parts":[[2013,2,4]],"date-time":"2013-02-04T13:07:33Z","timestamp":1359983253000},"page":"32-35","source":"Crossref","is-referenced-by-count":0,"title":["No Detection of the Retrovirus Xenotropic Murine Leukemia Virus-Related Virus in Individuals with Hemophilia"],"prefix":"10.1159","volume":"40","author":[{"given":"J\u00f6rg","family":"Sch\u00fcttrumpf","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.Kai","family":"Hourfar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonja","family":"Alesci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Miesbach","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erhard","family":"Seifried","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,1,3]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.0020025"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0906922106"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1126\/science.1179052"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1006901107"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3201\/eid1606.100066"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00268-09"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008519"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-7-10"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-6-92"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015632"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-7-224"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-7-63"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.3201\/eid1702.100978"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2010.08.003"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-326"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1186\/2040-2392-1-14"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-8-12"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.c1018"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/pros.21255"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1537-2995.2010.03012.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.12.028"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2008.04.016"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1126\/science.1212182"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-7-110"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-7-108"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-7-109"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0023484"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4690-7-112"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1126\/science.1213841"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1126\/science.333.6051.1810"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0018272"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1046\/j.1537-2995.1999.39111160.x"}],"container-title":["Transfusion 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