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The specificity of these developmental processes is achieved through a tight spatio-temporal regulation of Hh signaling. Mice with defective Hh signal exhibit a wide spectrum of anomalies, including Vertebral defects, Anal atresia, Cardiovascular anomalies, Tracheoesophageal fistula, Renal dysplasia, and Limb defects, that resemble strikingly the phenotypes observed in VACTERL association in humans. In this review, we summarize our current understanding of mammalian Hh signaling and highlight the relevance of various mouse models for studying the etiology and pathogenesis of VACTERL association. In addition, recent advances in genetic study for unraveling the complexity of genetic inheritance of VACTERL and the implication of the Sonic hedgehog pathway in disease pathogenesis are also discussed.<\/jats:p>","DOI":"10.1159\/000345725","type":"journal-article","created":{"date-parts":[[2012,12,13]],"date-time":"2012-12-13T14:33:50Z","timestamp":1355409230000},"page":"32-45","source":"Crossref","is-referenced-by-count":28,"title":["Sonic Hedgehog Signaling and VACTERL 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