{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T01:42:45Z","timestamp":1792028565329,"version":"4.4.0"},"reference-count":15,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>t(8;22)(p11;q11) is a rare but recurrent chromosome translocation that has been reported in 11 cases of myeloproliferative neoplasm or B-acute lymphoblastic leukemia. This translocation results in an in-frame fusion of &lt;i&gt;FGFR1&lt;\/i&gt; on 8p11 and &lt;i&gt;BCR&lt;\/i&gt; on 22q11, and causes constitutive activation of the tyrosine kinase of the BCR\/FGFR1 chimera protein. Here, we report the twelfth case of hematological tumor bearing t(8;22)(p11;q11). The bone marrow showed hypoplastic and tri-lineage dysplasia with 24.4% abnormal cells. The abnormal cells were not defined as myeloid or lymphoid morphologically, lacking a myeloperoxidase reaction. Flow cytometric analysis of the bone marrow cells revealed that the abnormal cells expressed CD13, CD33, CD34, and CD19, and that a fraction of the abnormal cells was positive for CD10. Southern blot analysis of the bone marrow cells showed rearrangement of the immunoglobulin heavy chain gene, a genetic hallmark of B-cell differentiation. Previously reported cases with t(8;22)(p11;q11) suggested an association between myeloid and B-lymphoid tumors, whereas other chromosome translocations involving &lt;i&gt;FGFR1&lt;\/i&gt; on 8p11 showed a link between myeloid and T-lymphoid tumors. Our observation supports that t(8;22)(p11;q11) might define a dual myeloid and B-lymphoid disorder.<\/jats:p>","DOI":"10.1159\/000345727","type":"journal-article","created":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T14:17:18Z","timestamp":1358173038000},"page":"238-242","source":"Crossref","is-referenced-by-count":16,"title":["Acute Leukemia Showing t(8;22)(p11;q11), Myelodysplasia, CD13\/CD33\/CD19 Expression and Immunoglobulin Heavy Chain Gene Rearrangement"],"prefix":"10.1159","volume":"129","author":[{"given":"Masaya","family":"Shimanuki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Sonoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Hosoi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyuri","family":"Watanuki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Murata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Mushino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kodai","family":"Kuriyama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinobu","family":"Tamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuo","family":"Hatanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyoshi","family":"Hanaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Nakakuma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,1,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.1195"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.13.3778"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038\/sj.thj.6200201"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20442"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.cancergencyto.2008.07.002"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20588"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.05.009"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2011.05.013"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2010.12.014"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(04)00053-4"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2009-05-217182"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0038265"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-009-0382-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159\/000046639"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2009.03.001"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345727","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345727","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345727","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:38:38Z","timestamp":1745433518000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000345727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,5,1]]},"published-print":{"date-parts":[[2013,5,15]]}},"URL":"https:\/\/doi.org\/10.1159\/000345727","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}