{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T04:24:49Z","timestamp":1745900689098,"version":"3.40.4"},"reference-count":28,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background:<\/i><\/b> Variation at the cyclin-dependent kinase inhibitor gene P21 in a patient sample of the Italian population was investigated in search of genetic factors potentially involved in sporadic late-onset Alzheimer\u2019s disease (AD). <b><i>Methods:<\/i><\/b> Two single nucleotide polymorphisms (SNPs) were studied in this gene: a C>A transversion at codon 31 (ser>arg) in exon 2 (RS1801270) and a C>T transition occurring 20 bp downstream from the stop codon of exon 3 (RS1059234). <b><i>Results:<\/i><\/b> The odd ratios were: RS1801270 A allele = 0.62 (95% CI = 0.33\u20131.18; p<i> = <\/i>0.14); RS1059234 T allele = 0.57 (95% CI = 0.33\u20130.98; p<i> = <\/i>0.04). In addition, a longer duration of disease was found with genotypes carrying the RS1059234 T allele (4.3 \u00b1 2.5 years) than with those not carrying it (3.3 \u00b1 2.1 years) (p = 0.001). <b><i>Conclusion:<\/i><\/b> In the present sample, one of the two SNPs seems in some way related to AD, since carriers of one allele were slightly protected against AD onset.<\/jats:p>","DOI":"10.1159\/000345788","type":"journal-article","created":{"date-parts":[[2013,1,14]],"date-time":"2013-01-14T07:53:03Z","timestamp":1358149983000},"page":"51-57","source":"Crossref","is-referenced-by-count":9,"title":["P21 Gene Variation and Late-Onset Alzheimer\u2019s Disease in the Italian Population"],"prefix":"10.1159","volume":"35","author":[{"given":"R.","family":"Scacchi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Gambina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Moretto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.M.","family":"Corbo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,1,9]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cell.2005.02.008"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2F349704a0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2F376775a0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2F375754a0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.1995.00540310012003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs000180050223"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2893%2991705-Q"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.90.5.1977"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000321984"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000221832"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000330472"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00702-009-0276-z"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2803%2900049-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-510X%2802%2900410-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2893%2990500-P"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1101%2Fgad.10.15.1945"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038%2F366701a0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.97.8.4291"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neulet.2012.03.093"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159%2F000330468"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2819970615%2979%3A12%3C2424%3A%3AAID-CNCR19%3E3.0.CO%3B2-T"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.34.7.939"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3956%2875%2990026-6"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093%2Fnar%2F16.3.1215"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2FS0197-4580%2800%2900246-3"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.mp.4001775"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1159%2F000154344"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1158%2F1055-9965.EPI-09-0140"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345788","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345788","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:39:15Z","timestamp":1745433555000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000345788"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":28,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2013,2,1]]},"published-print":{"date-parts":[[2013,2,28]]}},"URL":"https:\/\/doi.org\/10.1159\/000345788","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"type":"print","value":"1420-8008"},{"type":"electronic","value":"1421-9824"}],"subject":[],"published":{"date-parts":[[2013]]}}}