{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T12:32:15Z","timestamp":1790512335108,"version":"4.1.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cardiology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; In recent studies, concentrations of cell-free circulating DNA (cf-DNA) have been correlated with clinical characteristics and prognosis in several diseases. The relationship between cf-DNA concentrations and the acute coronary syndrome (ACS) remains unknown. Moreover, no data are available for the detection cf-DNA in ACS by a branched DNA (bDNA)-based Alu assay. The aim of the present study was to investigate cf-DNA concentrations in ACS and their relationship with clinical features. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Plasma cf-DNA concentrations of 137 ACS patients at diagnosis, of 60 healthy individuals and of 13 patients with stable angina (SA) were determined using a bDNA-based Alu assay. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; ACS patients (median 2,285.0, interquartile range 916.4\u20134,857.3 ng\/ml), especially in ST-segment elevation myocardial infarction patients (median 5,745.4, interquartile range 4,013.5\u20138,643.9 ng\/ml), showed a signi&amp;#xFB01;cant increase in plasma cf-DNA concentrations compared with controls (healthy controls: median 118.3, interquartile range 81.1\u2013221.1 ng\/ml; SA patients: median 202.3, interquartile range 112.7\u2013256.1 ng\/ml) using a bDNA-based Alu assay. Moreover, we found positive correlations between cf-DNA and Gensini scoring and GRACE (Global Registry of Acute Coronary Events) scoring in ACS. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; cf-DNA may be a valuable marker for diagnosing and predicting the severity of coronary artery lesions and risk stratification in ACS.<\/jats:p>","DOI":"10.1159\/000345855","type":"journal-article","created":{"date-parts":[[2013,2,4]],"date-time":"2013-02-04T13:07:33Z","timestamp":1359983253000},"page":"76-84","source":"Crossref","is-referenced-by-count":58,"title":["Cell-Free Circulating DNA: A New Biomarker for the Acute Coronary Syndrome"],"prefix":"10.1159","volume":"124","author":[{"given":"Ming","family":"Cui","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengkang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongrong","family":"Jing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huimin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingfeng","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongzhuan","family":"Sheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueguo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lurong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianhua","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoqing","family":"Ju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,1,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejca.2012.02.066"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1371%2Fjournal.pone.0035426"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2Fjor.20911"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0009-8981%2802%2900337-6"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109%2F17482941.2010.513732"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1196%2Fannals.1368.037"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjcard.2008.07.024"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fneuonc%2Fnop041"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1158%2F0008-5472.CAN-09-1705"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10067-009-1245-5"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clinbiochem.2011.06.083"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2883%2980105-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1053%2Feuhj.2001.3081"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.pharmthera.2004.07.005"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1086%2F302205"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1067%2Fmhj.2001.112404"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra071014"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11239-010-0531-z"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097%2FSMJ.0b013e3181ccb3d7"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1371%2Fjournal.pone.0031455"}],"container-title":["Cardiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345855","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345855","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/345855","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:39:51Z","timestamp":1745433591000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000345855"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":20,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,3,1]]},"published-print":{"date-parts":[[2013,3,8]]}},"URL":"https:\/\/doi.org\/10.1159\/000345855","archive":["Portico"],"relation":{},"ISSN":["0008-6312","1421-9751"],"issn-type":[{"value":"0008-6312","type":"print"},{"value":"1421-9751","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}