{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:16:59Z","timestamp":1759565819100,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; In recent years, epidemiological data showed that the incidence of ectopic pregnancies (EP) is decreasing, but few data are available on the time trend in Southern European populations. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Using data from the Lombardy Region Database, we calculated and standardized the EP rates\/10,000 resident women and the ratios\/1,000 pregnancies. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Data regarding 1,777,011 pregnancies and 17,028 cases of EP were recorded among women resident in Lombardy between 1996 and 2010, aged 15-50 years old. The age-adjusted EP rates increased from 4.4 in 1996 to 5.8 in 2010. The age-adjusted EP ratio was 9.4\/1,000 pregnancies in 1996 and 9.8 in 2010. Medical treatment increased over the period; the proportion of laparoscopic treatment increased from 25.9% in 1996 to 36.3% in 2010. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; The age-adjusted EP rate and ratio increased between 1996 and 2010, suggesting that the significance of EP as a public health problem has increased in the last years.<\/jats:p>","DOI":"10.1159\/000346173","type":"journal-article","created":{"date-parts":[[2013,4,4]],"date-time":"2013-04-04T08:35:36Z","timestamp":1365064536000},"page":"210-214","source":"Crossref","is-referenced-by-count":8,"title":["Temporal Trend in the Frequency of Ectopic Pregnancies in Lombardy, Italy"],"prefix":"10.1159","volume":"75","author":[{"given":"Fabio","family":"Parazzini","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Ricci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sonia","family":"Cipriani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Chiaffarino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vito","family":"Chiantera","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Bulfoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,3,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0412.1997.tb07990.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb13233.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)64643-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1988.tb06546.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.282.6257.15"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del289"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1479-828X.2001.tb01325.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.3109\/01443610903477556"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3181d0c328"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097\/01.AOG.0000158860.26939.2d"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.316.7147.1776"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136\/sti.76.1.28"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh399"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016\/0010-7824(88)90146-1"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmp057"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(97)80064-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.7.1804"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2010.11.016"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.06.041"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2010.12.026"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/346173","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/346173","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/346173","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:43:18Z","timestamp":1745433798000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000346173"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":20,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,4,1]]},"published-print":{"date-parts":[[2013,4,17]]}},"URL":"https:\/\/doi.org\/10.1159\/000346173","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"type":"print","value":"0378-7346"},{"type":"electronic","value":"1423-002X"}],"subject":[],"published":{"date-parts":[[2013]]}}}