{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:02:16Z","timestamp":1789704136394,"version":"4.0.1"},"reference-count":25,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2012,1,1]],"date-time":"2012-01-01T00:00:00Z","timestamp":1325376000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2012]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Generalized pustular psoriasis (GPP) is a severe inflammatory disease characterized by recurrent eruptions of sterile pustules on erythematous skin. Although tumor necrosis factor (TNF) antagonists may lead to a rapid resolution of GPP, the mechanism of action of these agents remains to be investigated. Here, we sought to evaluate markers of immune response in the skin of a patient who experienced a rapid amelioration of GPP after treatment with infliximab and acitretin. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; A skin biopsy was obtained before and 72 h after initiation of treatment. Immunohistochemical stainings were performed to characterize alterations of the infiltrates, the apoptosis marker caspase 3 and key cytokines like TNF\u03b1, interleukin (IL)-12, IL-23 and the chemokine CXCL8\/IL-8. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Parallel with clinical improvement, a striking decline of neutrophils, myeloid and plasmacytoid dendritic cells, M1 macrophages and partly of CD4+ T cells was observed. There was no evidence of increased apoptosis mediated through the caspase-3 pathway. A marked reduction particularly of IL-12 and IL-23 and, to a lesser degree, of TNF\u03b1 and CXCL8\/IL-8 was observed. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; A swift clinical improvement of GPP by infliximab and acitretin is associated with a marked reduction particularly of innate and partially of the acquired immune cells as well as IL-12 and IL-23.<\/jats:p>","DOI":"10.1159\/000346243","type":"journal-article","created":{"date-parts":[[2013,1,18]],"date-time":"2013-01-18T07:42:47Z","timestamp":1358494967000},"page":"338-343","source":"Crossref","is-referenced-by-count":20,"title":["Rapid Downregulation of Innate Immune Cells, Interleukin-12 and Interleukin-23 in Generalized Pustular Psoriasis with Infliximab in Combination with Acitretin"],"prefix":"10.1159","volume":"225","author":[{"given":"M.M.","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Z.","family":"Spanou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Schibler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Pelivani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Yawalkar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,1,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2165\/11586900-000000000-00000"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.128382"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05719.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-0960.2009.00588.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.08.025"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2009.06.082"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0509736102"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05960.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2009.01.003"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.10"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1013068"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.07.016"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5701213"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.09995.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159\/000167802"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20050500"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.10.1777"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1021\/tx900086v"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2007.00800.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.06816.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.07945.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2006.05.004"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2003.018085"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2007.06.006"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-008-9233-0"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/346243","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/346243","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:44:26Z","timestamp":1745433866000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000346243"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2013,3,1]]},"published-print":{"date-parts":[[2013,3,7]]}},"URL":"https:\/\/doi.org\/10.1159\/000346243","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012]]}}}