{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T13:21:30Z","timestamp":1782739290284,"version":"3.54.5"},"reference-count":21,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroepidemiology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Hereditary ataxias (HA) comprise a group of genetically heterogeneous rare diseases. As important public health problems to be monitored, this study analyses the morbimortality of HA in Spain. &lt;b&gt;&lt;i&gt;Methods:&lt;\/i&gt;&lt;\/b&gt; Data were extracted from the national death index (1981-2008), using the International Classification of Diseases (ICD) 9th revision code 334 until 1998, and 10th revision code G11 from 1999 onwards. ICD-9 codes were then selected from the national discharge dataset (1998-2007). Age-adjusted morbidity and mortality rates were obtained by gender and 5-year period. &lt;b&gt;&lt;i&gt;Results:&lt;\/i&gt;&lt;\/b&gt; Of the 610 HA deaths from 1981 to 2008, 277 corresponded to Friedreich's ataxia (45.4%) and 333 (54.6%) to other and unspecified ataxias (non-Friedreich group). Both groups showed an increase in mortality trend, which was more pronounced in males from 1985-1989 to 1990-1994. Geographical distribution of mortality revealed higher risk for males, mainly in the north of Spain. A total of 5,341 HA hospitalisations were identified from 1998 to 2007. The average annual age-adjusted hospitalisation rate was 1.19 per 100,000 population, with a rising trend. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; This increase in morbidity and mortality, coupled with the slight interprovincial differences, indicate that more attention should be paid to these rare diseases by public authorities and society alike.<\/jats:p>","DOI":"10.1159\/000346275","type":"journal-article","created":{"date-parts":[[2013,3,21]],"date-time":"2013-03-21T13:44:48Z","timestamp":1363873488000},"page":"13-19","source":"Crossref","is-referenced-by-count":10,"title":["Epidemiology of Hereditary Ataxias in Spain: Hospital Discharge Registry and Population-Based Mortality Study"],"prefix":"10.1159","volume":"41","author":[{"given":"Ver\u00f3nica","family":"Alonso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Villaverde-Hueso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel J.","family":"Hens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Morales-Piga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Abaitua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Posada de la Paz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,3,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-51892-7.00014-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2009.10.001"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002\/mds.21798"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.58.5.702"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awp056"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.2005.00400.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/114.2.855"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02715.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159\/000110795"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1980.10477521"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkm271"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2010.01.004"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1001\/archneurol.2010.168"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2009.26"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540290042016"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159\/000110182"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1002\/mds.20687"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007\/s00439-001-0642-x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1159\/000080092"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1007\/s004390050997"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02637.x"}],"container-title":["Neuroepidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/346275","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/346275","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:44:37Z","timestamp":1745433877000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000346275"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":21,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2013,6,1]]},"published-print":{"date-parts":[[2013,6,27]]}},"URL":"https:\/\/doi.org\/10.1159\/000346275","archive":["Portico"],"relation":{},"ISSN":["0251-5350","1423-0208"],"issn-type":[{"value":"0251-5350","type":"print"},{"value":"1423-0208","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}