{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T02:29:35Z","timestamp":1782872975672,"version":"3.54.5"},"reference-count":39,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2013]]},"abstract":"<b><i>Background:<\/i><\/b> Immunoglobulin E (IgE) reactivity to individual allergens among cockroach-allergic patients has revealed wide variability. The aim of this study was to assess the effectiveness of recombinant cockroach allergens for skin testing, and to determine sensitization profiles among cockroach-allergic patients living in Brazil. <b><i>Methods:<\/i><\/b> Fifty-seven cockroach-allergic patients with asthma and\/or rhinitis were recruited. Skin testing with recombinant (r) allergens from <i>Periplaneta americana<\/i> (rPer a 1 and rPer a 7) and <i>Blattella germanica <\/i>(rBla g 2, rBla g 4 and rBla g 5) were performed at 10 \u03bcg\/ml and 5 \u03bcg\/ml (rPer a 1). IgE antibodies to rPer a 7 and rPer a 1 were quantitated by ELISA. <b><i>Results:<\/i><\/b> Of 57 patients tested, 3 (5.3%), 24 (42.1%), 4 (7%), 3 (5.3%) and 4 (7%) showed positive reactions to rPer a 1, rPer a 7, rBla g 2, rBla g 4 and rBla g 5, respectively. Twenty-eight patients (49.1%) had positive tests to at least one allergen. In keeping with skin test results, 31\/57 patients (54.4%) and 5\/55 patients (9%) had detectable IgE to rPer a 7 and rPer a 1, respectively. Levels of IgE to rPer a 7 were higher in patients with positive tests to rPer a 7 than those with negative tests (geometric mean 13.2 and 1.8 IU\/ml, p < 0.05). There was good concordance of results of skin tests and measurements of serum IgE to rPer a 7. <b><i>Conclusion:<\/i><\/b> IgE reactivity to rPer a 7 (<i>P. americana<\/i> tropomyosin) was dominant among patients in Brazil. However, 50% of the patients did not present reactivity to any of the recombinant allergens tested.<\/jats:p>","DOI":"10.1159\/000346318","type":"journal-article","created":{"date-parts":[[2013,3,15]],"date-time":"2013-03-15T14:39:09Z","timestamp":1363358349000},"page":"213-219","source":"Crossref","is-referenced-by-count":26,"title":["Efficacy of Recombinant Allergens for Diagnosis of Cockroach Allergy in Patients with Asthma and\/or Rhinitis"],"prefix":"10.1159","volume":"161","author":[{"given":"Michelle C.R.","family":"Barbosa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Beatriz R.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia P.L.","family":"Ferriani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pom\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin D.","family":"Chapman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.Karla","family":"Arruda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2013,3,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.112854"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199705083361904"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.01.036"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03327.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.2174\/092986607782541178"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002\/pmic.201000348"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111\/j.1744-313X.2007.00697.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M807209200"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.02.017"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70375-1"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2007.01602.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02112.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2002.01397.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2007.02751.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.3109\/02770908809071367"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2011.02480.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.1999.00653.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2010.03585.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.03.017"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.10.008"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2008.01748.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.04.024"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.52.31196"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70393-8"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.272.33.20907"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(99)70430-6"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(90)90223-Q"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2745.2002.01455.x"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70083-6"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2005.01.018"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2008.02048.x"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2003.01540.x"},{"key":"ref33","doi-asserted-by":"publisher","DOI":"10.1093\/bmb\/ldl015"},{"key":"ref34","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200603-331OC"},{"key":"ref35","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2007.12.1147"},{"key":"ref36","doi-asserted-by":"publisher","DOI":"10.1159\/000321106"},{"key":"ref37","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2583.2004.00530.x"},{"key":"ref38","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.01.023"},{"key":"ref39","doi-asserted-by":"publisher","DOI":"10.1159\/000077356"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/346318","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/346318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:45:00Z","timestamp":1745433900000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000346318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":39,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,6,1]]},"published-print":{"date-parts":[[2013,6,13]]}},"URL":"https:\/\/doi.org\/10.1159\/000346318","archive":["Portico"],"relation":{"is-supplemented-by":[{"id-type":"doi","id":"10.6084\/m9.figshare.5124445","asserted-by":"subject"}]},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013]]}}}