{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T13:52:43Z","timestamp":1758981163654,"version":"3.40.4"},"reference-count":13,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2013,1,1]],"date-time":"2013-01-01T00:00:00Z","timestamp":1356998400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2013]]},"abstract":"<jats:p>&lt;b&gt;&lt;i&gt;Background:&lt;\/i&gt;&lt;\/b&gt; Subacute cutaneous lupus erythematosus (SCLE) can be induced by numerous drugs. We report 3 cases of SCLE induced by proton pump inhibitors (PPIs). &lt;b&gt;&lt;i&gt;Objective:&lt;\/i&gt;&lt;\/b&gt; To highlight a rare cutaneous side effect induced by a frequently prescribed drug such as a PPI. &lt;b&gt;&lt;i&gt;Case Reports:&lt;\/i&gt;&lt;\/b&gt; Case 1 was a 30-year-old man who developed multiple annular plaques over the trunk and lower limbs 1 month after the initiation of pantoprazole. Antinuclear antibodies (ANA) were positive with anti-Ro\/SSA and anti-La\/SSB antibodies, and histology confirmed the diagnosis. Clinical improvement was achieved 8 weeks after the discontinuation of pantoprazole and the introduction of a treatment combining topical steroids and hydroxychloroquine. Lesions relapsed when pantoprazole was accidentally rechallenged. The second case was a 31-year-old woman, 28 weeks pregnant, who presented erythematous annular plaques over the trunk 7 weeks after starting esomeprazole. ANA and anti-Ro\/SSA antibodies were positive, and the histology was compatible with SCLE. Fetal ultrasound was normal. She was treated with topical and oral steroids and hydroxychloroquine. Clinical improvement was achieved 4 weeks after the discontinuation of esomeprazole. The third case was a 57-year-old woman with systemic erythematosus lupus presenting annular and psoriasiform lesions on the trunk for 15 months. She was treated successively with hydroxychloroquine, azathioprine, mycophenolate mofetil and methotrexate with prednisone. A review of her drug history revealed the introduction of omeprazole a few weeks before the first appearance of skin lesions and omeprazole was contraindicated. &lt;b&gt;&lt;i&gt;Conclusion:&lt;\/i&gt;&lt;\/b&gt; SCLE should systematically be suspected in case of eruption after the introduction of PPI. The risk of fetal cardiac complications is important in pregnant women.<\/jats:p>","DOI":"10.1159\/000346694","type":"journal-article","created":{"date-parts":[[2013,3,25]],"date-time":"2013-03-25T07:58:21Z","timestamp":1364198301000},"page":"119-123","source":"Crossref","is-referenced-by-count":14,"title":["Subacute Cutaneous Lupus Erythematosus Induced and Exacerbated by Proton Pump Inhibitors"],"prefix":"10.1159","volume":"226","author":[{"given":"Mishal","family":"Almebayadh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elodie","family":"Regnier-Rosencher","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agn\u00e8s","family":"Carlotti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Goulvestre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e9ronique","family":"Le Guern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luc","family":"Mouthon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Fran\u00e7oise","family":"Avril","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Dupin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,3,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2010.10110.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-0335"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1177\/0961203307087189"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2010.03926.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03125.x"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2011.04245.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1080\/00015550510026668"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.03105.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.10969.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.114565"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2011.10397.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1177\/0961203309106176"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016\/j.berh.2012.01.014"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/346694","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/346694","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:49:04Z","timestamp":1745434144000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000346694"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":13,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2013,6,1]]},"published-print":{"date-parts":[[2013,6,21]]}},"URL":"https:\/\/doi.org\/10.1159\/000346694","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"type":"print","value":"1018-8665"},{"type":"electronic","value":"1421-9832"}],"subject":[],"published":{"date-parts":[[2013]]}}}