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After treatment with prednisone, adrenal hormones normalised but testosterone remained elevated. Magnetic resonance imaging of the abdomen due to cryptorchidism revealed uterus and adnexal attachments, a prostate and poorly defined nodules on the iliac chains. Upon exploratory laparotomy, a hysterectomy, bilateral oophorectomy and resection of a peri-adnexal nodular lesion on the patient's right side were performed. Histopathology of the nodule mass was compatible with a Leydig cell tumour with a low proliferation rate according to Ki67.<\/jats:p>","DOI":"10.1159\/000346899","type":"journal-article","created":{"date-parts":[[2013,2,25]],"date-time":"2013-02-25T08:18:13Z","timestamp":1361780293000},"page":"179-184","source":"Crossref","is-referenced-by-count":3,"title":["Leydig Cell Tumour in a 46,XX Child with Congenital Adrenal Hyperplasia due to 21-Hydroxylase Deficiency"],"prefix":"10.1159","volume":"79","author":[{"given":"Ana Paula Pires","family":"L\u00e1zaro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriano Machado","family":"de Lacerda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juraci","family":"Ghiaroni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luiz Carlos Duarte","family":"de Miranda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Paula Aguiar","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Ferrez","family":"Collett-Solberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora de Paula","family":"Michelatto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maricilda Palandi","family":"Mello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marilia Martins","family":"Guimar\u00e3es","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2013,2,23]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1210\/jc.2001-011939"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1210\/jc.2007-2594"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1530\/eje.0.1420619"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1159\/000291506"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1590\/S0004-27302005000500018"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1111\/j.1471-0528.1984.tb04749.x"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1111\/j.1365-2265.2008.03389.x"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1007\/s00063-007-1032-5"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1016\/j.fertnstert.2010.01.035"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1055\/s-2007-1023795"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1111\/j.1365-2265.1994.tb01820.x"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1210\/jc.2010-0714"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1155\/2010\/982025"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1590\/S0004-27302009000600001"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1590\/S0004-27302009000600004"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1515\/JPEM.2000.13.6.663"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.4158\/EP.14.3.358"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/346899","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/346899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T18:51:03Z","timestamp":1745434263000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000346899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2013,4,1]]},"published-print":{"date-parts":[[2013,4,19]]}},"URL":"https:\/\/doi.org\/10.1159\/000346899","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2013]]}}}